Literature DB >> 22886498

Glutathione regulates the transfer of iron-sulfur cluster from monothiol and dithiol glutaredoxins to apo ferredoxin.

Lei Wang1, Bingjie Ouyang, Yifei Li, Yingang Feng, Jean-Pierre Jacquot, Nicolas Rouhier, Bin Xia.   

Abstract

Holo glutaredoxin (Grx) is a homo-dimer that bridges a [2Fe-2S] cluster with two glutathione (GSH) ligands. In this study, both monothiol and dithiol holo Grxs are found capable of transferring their iron-sulfur (FeS) cluster to an apo ferredoxin (Fdx) through direct interaction, regardless of FeS cluster stability in holo Grxs. The ligand GSH molecules in holo Grxs are unstable and can be exchanged with free GSH, which inhibits the FeS cluster transfer from holo Grxs to apo Fdx. This phenomenon suggests a novel role of GSH in FeS cluster trafficking.

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Year:  2012        PMID： 22886498      PMCID： PMC4875373          DOI： 10.1007/s13238-012-2051-4

Source DB:  PubMed          Journal:  Protein Cell        ISSN： 1674-800X            Impact factor:   14.870


  29 in total

1.  Arabidopsis chloroplastic glutaredoxin C5 as a model to explore molecular determinants for iron-sulfur cluster binding into glutaredoxins.

Authors:  Jérémy Couturier; Elke Ströher; Angela-Nadia Albetel; Thomas Roret; Meenakumari Muthuramalingam; Lionel Tarrago; Thorsten Seidel; Pascale Tsan; Jean-Pierre Jacquot; Michael K Johnson; Karl-Josef Dietz; Claude Didierjean; Nicolas Rouhier
Journal:  J Biol Chem       Date:  2011-06-01       Impact factor: 5.157

2.  Subcellular distribution of glutathione in the gametophyte.

Authors:  Bernd Zechmann; Scott D Russell
Journal:  Plant Signal Behav       Date:  2011-09

3.  1H, 15N, and 13C resonance assignments of reduced glutaredoxin C1 from Populus tremula x tremuloides.

Authors:  Yingang Feng; Nicolas Rouhier; Jean-Pierre Jacquot; Bin Xia
Journal:  J Biomol NMR       Date:  2005-03       Impact factor: 2.835

4.  Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.

Authors:  Ulrich Mühlenhoff; Sabine Molik; José R Godoy; Marta A Uzarska; Nadine Richter; Andreas Seubert; Yan Zhang; JoAnne Stubbe; Fabien Pierrel; Enrique Herrero; Christopher Horst Lillig; Roland Lill
Journal:  Cell Metab       Date:  2010-10-06       Impact factor: 27.287

5.  Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor.

Authors:  Christopher Horst Lillig; Carsten Berndt; Olivia Vergnolle; Maria Elisabet Lönn; Christoph Hudemann; Eckhard Bill; Arne Holmgren
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-25       Impact factor: 11.205

6.  A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's disease.

Authors:  Donna W Lee; Deepinder Kaur; Shankar J Chinta; Subramanian Rajagopalan; Julie K Andersen
Journal:  Antioxid Redox Signal       Date:  2009-09       Impact factor: 8.401

7.  Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: role of redox chemistry and a conserved aspartate.

Authors:  Shu-Pao Wu; Gong Wu; Kristene K Surerus; J A Cowan
Journal:  Biochemistry       Date:  2002-07-16       Impact factor: 3.162

Review 8.  Glutaredoxin systems.

Authors:  Christopher Horst Lillig; Carsten Berndt; Arne Holmgren
Journal:  Biochim Biophys Acta       Date:  2008-06-18

Review 9.  The role of glutathione in photosynthetic organisms: emerging functions for glutaredoxins and glutathionylation.

Authors:  Nicolas Rouhier; Stéphane D Lemaire; Jean-Pierre Jacquot
Journal:  Annu Rev Plant Biol       Date:  2008       Impact factor: 26.379

Review 10.  Glutaredoxins: roles in iron homeostasis.

Authors:  Nicolas Rouhier; Jérémy Couturier; Michael K Johnson; Jean-Pierre Jacquot
Journal:  Trends Biochem Sci       Date:  2009-10-05       Impact factor: 13.807
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  9 in total

1.  Mapping cellular Fe-S cluster uptake and exchange reactions - divergent pathways for iron-sulfur cluster delivery to human ferredoxins.

Authors:  Insiya Fidai; Christine Wachnowsky; J A Cowan
Journal:  Metallomics       Date:  2016-12-07       Impact factor: 4.526

2.  Role of protein-glutathione contacts in defining glutaredoxin-3 [2Fe-2S] cluster chirality, ligand exchange and transfer chemistry.

Authors:  Sambuddha Sen; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2017-08-23       Impact factor: 3.358

3.  Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking.

Authors:  Insiya Fidai; Christine Wachnowsky; J A Cowan
Journal:  J Biol Inorg Chem       Date:  2016-09-02       Impact factor: 3.358

4.  [2Fe-2S] cluster transfer in iron-sulfur protein biogenesis.

Authors:  Lucia Banci; Diego Brancaccio; Simone Ciofi-Baffoni; Rebecca Del Conte; Ravisekhar Gadepalli; Maciej Mikolajczyk; Sara Neri; Mario Piccioli; Julia Winkelmann
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-14       Impact factor: 11.205

5.  Characterization of poplar GrxS14 in different structural forms.

Authors:  Lei Wang; Yifei Li; Jean-Pierre Jacquot; Nicolas Rouhier; Bin Xia
Journal:  Protein Cell       Date:  2014-05       Impact factor: 14.870

6.  Regulation of Class A β-Lactamase CzoA by CzoR and IscR in Comamonas testosteroni S44.

Authors:  Weiping Zhuang; Hongliang Liu; Jingxin Li; Lu Chen; Gejiao Wang
Journal:  Front Microbiol       Date:  2017-12-22       Impact factor: 5.640

Review 7.  Thioredoxin and Glutaredoxin Systems as Potential Targets for the Development of New Treatments in Friedreich's Ataxia.

Authors:  Marta Seco-Cervera; Pilar González-Cabo; Federico V Pallardó; Carlos Romá-Mateo; José Luis García-Giménez
Journal:  Antioxidants (Basel)       Date:  2020-12-10

8.  Identification and Function of Apicoplast Glutaredoxins in Neospora caninum.

Authors:  Xingju Song; Xu Yang; Zhu Ying; Heng Zhang; Jing Liu; Qun Liu
Journal:  Int J Mol Sci       Date:  2021-11-04       Impact factor: 5.923

9.  Global Regulator IscR Positively Contributes to Antimonite Resistance and Oxidation in Comamonas testosteroni S44.

Authors:  Hongliang Liu; Weiping Zhuang; Shengzhe Zhang; Christopher Rensing; Jun Huang; Jie Li; Gejiao Wang
Journal:  Front Mol Biosci       Date:  2015-12-18
  9 in total

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