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Literature DB >> 22886014

Streptozotocin-induced sporadic Alzheimer's disease: selection of appropriate dose.

Jogender Mehla¹, Monika Pahuja, Yogendra Kumar Gupta.

Abstract

The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.

Entities: Chemical Disease Species

Mesh：

Substances：
Streptozocin

Year: 2013 PMID： 22886014 DOI： 10.3233/JAD-2012-120958

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472

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Cited

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