Literature DB >> 22885978

c-Rel: shaping CD4 regulatory T cell development in unexpected ways.

Steve Gerondakis1, Tom Fulford, Raelene J Grumont.   

Abstract

In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings about how the c-Rel transcription factor orchestrates this developmental process.

Entities:  

Keywords:  Foxp3; T cell receptor; c-Rel; epigenetic regulation; interleukin 2; regulatory T cells; transcription

Mesh：

Substances：

Year:  2012        PMID： 22885978      PMCID： PMC3632621          DOI： 10.4161/trns.21309

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  30 in total

Review 1.  Roles of the NF-kappaB pathway in lymphocyte development and function.

Authors:  Steve Gerondakis; Ulrich Siebenlist
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-23       Impact factor: 10.005

Review 2.  c-Rel: a pioneer in directing regulatory T-cell lineage commitment?

Authors:  Shohei Hori
Journal:  Eur J Immunol       Date:  2010-03       Impact factor: 5.532

3.  Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

Authors:  Kieng B Vang; Jianying Yang; Antonio J Pagán; Lin-Xi Li; Junmei Wang; Jonathan M Green; Amer A Beg; Michael A Farrar
Journal:  J Immunol       Date:  2010-03-12       Impact factor: 5.422

Review 4.  Becoming self-aware: the thymic education of regulatory T cells.

Authors:  Chan-Wang J Lio; Chyi-Song Hsieh
Journal:  Curr Opin Immunol       Date:  2010-12-14       Impact factor: 7.486

5.  Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

Authors:  Ye Zheng; Steven Z Josefowicz; Arnold Kas; Tin-Tin Chu; Marc A Gavin; Alexander Y Rudensky
Journal:  Nature       Date:  2007-01-21       Impact factor: 49.962

6.  c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

Authors:  Iwao Isomura; Stephanie Palmer; Raelene J Grumont; Karen Bunting; Gerard Hoyne; Nancy Wilkinson; Ashish Banerjee; Anna Proietto; Raffi Gugasyan; Li Wu; Wu Li; Alice McNally; Raymond J Steptoe; Ranjeny Thomas; M Frances Shannon; Steve Gerondakis
Journal:  J Exp Med       Date:  2009-12-07       Impact factor: 14.307

7.  Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.

Authors:  Matthias Farlik; Benjamin Reutterer; Christian Schindler; Florian Greten; Claus Vogl; Mathias Müller; Thomas Decker
Journal:  Immunity       Date:  2010-07-23       Impact factor: 31.745

8.  Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

Authors:  Qingguo Ruan; Vasumathi Kameswaran; Yukiko Tone; Li Li; Hsiou-Chi Liou; Mark I Greene; Masahide Tone; Youhai H Chen
Journal:  Immunity       Date:  2009-12-18       Impact factor: 31.745

9.  c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

Authors:  George Grigoriadis; Ajithkumar Vasanthakumar; Ashish Banerjee; Raelene Grumont; Sarah Overall; Paul Gleeson; Frances Shannon; Steve Gerondakis
Journal:  PLoS One       Date:  2011-10-31       Impact factor: 3.240

10.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

Authors:  Ye Zheng; Steven Josefowicz; Ashutosh Chaudhry; Xiao P Peng; Katherine Forbush; Alexander Y Rudensky
Journal:  Nature       Date:  2010-01-13       Impact factor: 49.962
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