Literature DB >> 22885977

Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis.

Vanessa Gobert1, Marc Haenlin, Lucas Waltzer.   

Abstract

Even though deregulation of human MLF1, the founding member of the Myeloid Leukemia Factor family, has been associated with acute myeloid leukemia, the function and mode of action of this family of genes have remained rather mysterious. Yet, recent findings in Drosophila shed new light on their biological activity and suggest that they play an important role in hematopoiesis and leukemia, notably by regulating the stability of RUNX transcription factors, another family of conserved proteins with prominent roles in normal and malignant blood cell development.

Entities:  

Keywords:  Drosophila; MLF; RUNX; hematopoiesis; leukemia

Mesh：

Substances：

Year:  2012        PMID： 22885977      PMCID： PMC3632622          DOI： 10.4161/trns.21490

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  30 in total

1.  Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome.

Authors:  N Matsumoto; N Yoneda-Kato; T Iguchi; Y Kishimoto; T Kyo; H Sawada; E Tatsumi; S Fukuhara
Journal:  Leukemia       Date:  2000-10       Impact factor: 11.528

2.  Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF).

Authors:  K Ohno; Y Takahashi; F Hirose; Y H Inoue; O Taguchi; Y Nishida; A Matsukage; M Yamaguchi
Journal:  Gene       Date:  2000-12-30       Impact factor: 3.688

3.  HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.

Authors:  J H Williams; L N Daly; E Ingley; J G Beaumont; P A Tilbrook; J P Lalonde; J P Stillitano; S P Klinken
Journal:  EMBO J       Date:  1999-10-15       Impact factor: 11.598

4.  Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation.

Authors:  G Huang; K Shigesada; K Ito; H J Wee; T Yokomizo; Y Ito
Journal:  EMBO J       Date:  2001-02-15       Impact factor: 11.598

5.  MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.

Authors:  Raelene Lim; Louise N Winteringham; James H Williams; Ross K McCulloch; Evan Ingley; Jim Y-H Tiao; Jean-Philippe Lalonde; Schickwann Tsai; Peta A Tilbrook; Yi Sun; Xiaohua Wu; Stephan W Morris; S Peter Klinken
Journal:  J Biol Chem       Date:  2002-08-09       Impact factor: 5.157

6.  cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.

Authors:  Silva H Hanissian; Umar Akbar; Bin Teng; Zorica Janjetovic; Anne Hoffmann; Johann K Hitzler; Norman Iscove; Kristin Hamre; Xiaoping Du; Yiai Tong; Suraj Mukatira; Jon H Robertson; Stephan W Morris
Journal:  Oncogene       Date:  2004-04-29       Impact factor: 9.867

7.  The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

Authors:  N Yoneda-Kato; A T Look; M N Kirstein; M B Valentine; S C Raimondi; K J Cohen; A J Carroll; S W Morris
Journal:  Oncogene       Date:  1996-01-18       Impact factor: 9.867

8.  Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1.

Authors:  Parsa Kazemi-Esfarjani; Seymour Benzer
Journal:  Hum Mol Genet       Date:  2002-10-01       Impact factor: 6.150

9.  Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation.

Authors:  Louise Natalie Winteringham; Simon Kobelke; James Howard Williams; Evan Ingley; Svend Peter Klinken
Journal:  Oncogene       Date:  2004-06-24       Impact factor: 9.867

10.  Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis.

Authors:  Sylvaine Fouix; Séverine Martin-Lannerée; Matthieu Sanial; Luciana Morla; Claudie Lamour-Isnard; Anne Plessis
Journal:  Genes Cells       Date:  2003-11       Impact factor: 1.891
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  5 in total

1.  Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression.

Authors:  Jamie O Dyer; Arnob Dutta; Madelaine Gogol; Vikki M Weake; George Dialynas; Xilan Wu; Christopher Seidel; Ying Zhang; Laurence Florens; Michael P Washburn; Susan M Abmayr; Jerry L Workman
Journal:  J Mol Biol       Date:  2016-10-27       Impact factor: 5.469

2.  Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis.

Authors:  Marion Miller; Aichun Chen; Vanessa Gobert; Benoit Augé; Mathilde Beau; Odile Burlet-Schiltz; Marc Haenlin; Lucas Waltzer
Journal:  PLoS Genet       Date:  2017-07-25       Impact factor: 5.917

3.  Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins.

Authors:  Manuela Molzan; Christian Ottmann
Journal:  Cell Mol Biol Lett       Date:  2012-12-27       Impact factor: 5.787

4.  Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome.

Authors:  Lisa Ma; Anthony W Herren; Glenda Espinal; Jamie Randol; Bridget McLaughlin; Veronica Martinez-Cerdeño; Isaac N Pessah; Randi J Hagerman; Paul J Hagerman
Journal:  Acta Neuropathol Commun       Date:  2019-09-03       Impact factor: 7.801

Review 5.  The Leukemic Fly: Promises and Challenges.

Authors:  Amani Al Outa; Dana Abubaker; Joelle Madi; Rihab Nasr; Margret Shirinian
Journal:  Cells       Date:  2020-07-21       Impact factor: 6.600
  5 in total

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