PURPOSE OF REVIEW: Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders. RECENT FINDINGS: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders. SUMMARY: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.
PURPOSE OF REVIEW: Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders. RECENT FINDINGS: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders. SUMMARY: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.
Authors: Hari K Somineni; Xue Zhang; Jocelyn M Biagini Myers; Melinda Butsch Kovacic; Ashley Ulm; Noelle Jurcak; Patrick H Ryan; Gurjit K Khurana Hershey; Hong Ji Journal: J Allergy Clin Immunol Date: 2015-12-10 Impact factor: 10.793
Authors: Daniel Aguilar; Nathanael Lemonnier; Gerard H Koppelman; Erik Melén; Baldo Oliva; Mariona Pinart; Stefano Guerra; Jean Bousquet; Josep M Anto Journal: PLoS One Date: 2019-11-06 Impact factor: 3.240
Authors: Jessica L Chandrasekhar; Kelly M Cox; William M Loo; Hui Qiao; Kenneth S Tung; Loren D Erickson Journal: J Immunol Date: 2019-07-03 Impact factor: 5.422
Authors: Kacper Packi; Joanna Matysiak; Sylwia Klimczak; Eliza Matuszewska; Anna Bręborowicz; Dagmara Pietkiewicz; Jan Matysiak Journal: Int J Environ Res Public Health Date: 2022-06-27 Impact factor: 4.614