OBJECTIVES: To investigate whether glutathione S-transferases (GST) genetic polymorphisms (GSTT1 rs1049055, GSTM1 rs10712361, and GSTP1 rs1695) are associated with susceptibility to noise-induced hearing loss (NIHL). METHODS: These polymorphisms were analyzed in 444 NIHL and 445 normal hearing workers. In addition, total plasma GST activity was measured in all subjects. RESULTS: Individuals with the GSTM1 null genotype had a statistically significantly increased risk of NIHL (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.26 to 2.13) compared with those carrying a wild-type GSTM1 genotype. This effect was more pronounced among the workers exposed to 86 to 91 dB(A) (OR = 3.35, 95% CI = 1.54 to 7.31). Glutathione S-transferase activity of the NIHL workers was also lower than that of normal hearing workers (14.5 ± 5.1 U/ml vs 15.9 ± 6.3 U/ml, P = 0.010). CONCLUSION: Our results suggest that GSTM1 polymorphism is associated with susceptibility to NIHL.
OBJECTIVES: To investigate whether glutathione S-transferases (GST) genetic polymorphisms (GSTT1 rs1049055, GSTM1 rs10712361, and GSTP1 rs1695) are associated with susceptibility to noise-induced hearing loss (NIHL). METHODS: These polymorphisms were analyzed in 444 NIHL and 445 normal hearing workers. In addition, total plasma GST activity was measured in all subjects. RESULTS: Individuals with the GSTM1 null genotype had a statistically significantly increased risk of NIHL (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.26 to 2.13) compared with those carrying a wild-type GSTM1 genotype. This effect was more pronounced among the workers exposed to 86 to 91 dB(A) (OR = 3.35, 95% CI = 1.54 to 7.31). Glutathione S-transferase activity of the NIHL workers was also lower than that of normal hearing workers (14.5 ± 5.1 U/ml vs 15.9 ± 6.3 U/ml, P = 0.010). CONCLUSION: Our results suggest that GSTM1 polymorphism is associated with susceptibility to NIHL.
Authors: Barna Budai; Péter Prekopp; László Noszek; Erika R Kovács; Márta Szőnyi; Dániel J Erdélyi; Krisztina Bíró; Lajos Géczi Journal: J Mol Med (Berl) Date: 2020-05-20 Impact factor: 4.599
Authors: Evangelia Tserga; Tara Nandwani; Niklas K Edvall; Jan Bulla; Poulam Patel; Barbara Canlon; Christopher R Cederroth; David M Baguley Journal: Sci Rep Date: 2019-03-05 Impact factor: 4.379
Authors: Arve Lie; Marit Skogstad; Håkon A Johannessen; Tore Tynes; Ingrid Sivesind Mehlum; Karl-Christian Nordby; Bo Engdahl; Kristian Tambs Journal: Int Arch Occup Environ Health Date: 2015-08-07 Impact factor: 3.015