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Literature DB >> 22885631

Fragmentation and unpredictability of early-life experience in mental disorders.

Tallie Z Baram¹, Elysia P Davis, Andre Obenaus, Curt A Sandman, Steven L Small, Ana Solodkin, Hal Stern.

Abstract

Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2012 PMID： 22885631 PMCID： PMC3483144 DOI： 10.1176/appi.ajp.2012.11091347

Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112

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