| Literature DB >> 22885409 |
Sangram Keshari Samal1, Mamoni Dash, Sandra Van Vlierberghe, David L Kaplan, Emo Chiellini, Clemens van Blitterswijk, Lorenzo Moroni, Peter Dubruel.
Abstract
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.Entities:
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Year: 2012 PMID： 22885409 DOI： 10.1039/c2cs35094g
Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564