PURPOSE: We sought to compare endothelial cell (EC) loss and graft survival after Descemet's stripping automated endothelial keratoplasty (DSAEK) and conventional penetrating keratoplasty (PK) in Asian eyes. DESIGN: Retrospective, nested, cohort study. PARTICIPANTS: Consecutive patients who underwent DSAEK or PK with Fuchs' endothelial dystrophy or pseudophakic and aphakic bullous keratopathy (BK) at a single tertiary center from April 1, 2006, to April 1, 2008. METHODS: Clinical data, and donor and recipient characteristics were recorded from our prospective cohort from the Singapore Corneal Transplant Study. MAIN OUTCOME MEASURES: Percent EC loss and graft survival up to 3 years. RESULTS: There were no differences in baseline characteristics of patients comparing DSAEK and PK; there were more patients with BK (n = 141, 68.4%) than Fuchs' dystrophy. Percent EC loss was lower in DSAEK compared with PK at 1 (30 ± 22% vs 37 ± 25%; P = 0.045), 2 (36 ± 23% vs 45 ± 33%; P = 0.018), and 3 years (39 ± 24% vs 47 ± 28%; P = 0.022) postoperatively. Graft survival was comparable (log-rank P = 0.671) between DSAEK and PK at 1 (94% vs 90%), 2 (88% vs 85%), and 3 years (87% vs 85%). CONCLUSIONS: Compared with PK, DSAEK resulted in lower EC loss with comparable cumulative graft survival rates for up to 3 years in patients with Fuchs' dystrophy and BK.
PURPOSE: We sought to compare endothelial cell (EC) loss and graft survival after Descemet's stripping automated endothelial keratoplasty (DSAEK) and conventional penetrating keratoplasty (PK) in Asian eyes. DESIGN: Retrospective, nested, cohort study. PARTICIPANTS: Consecutive patients who underwent DSAEK or PK with Fuchs' endothelial dystrophy or pseudophakic and aphakic bullous keratopathy (BK) at a single tertiary center from April 1, 2006, to April 1, 2008. METHODS: Clinical data, and donor and recipient characteristics were recorded from our prospective cohort from the Singapore Corneal Transplant Study. MAIN OUTCOME MEASURES: Percent EC loss and graft survival up to 3 years. RESULTS: There were no differences in baseline characteristics of patients comparing DSAEK and PK; there were more patients with BK (n = 141, 68.4%) than Fuchs' dystrophy. Percent EC loss was lower in DSAEK compared with PK at 1 (30 ± 22% vs 37 ± 25%; P = 0.045), 2 (36 ± 23% vs 45 ± 33%; P = 0.018), and 3 years (39 ± 24% vs 47 ± 28%; P = 0.022) postoperatively. Graft survival was comparable (log-rank P = 0.671) between DSAEK and PK at 1 (94% vs 90%), 2 (88% vs 85%), and 3 years (87% vs 85%). CONCLUSIONS: Compared with PK, DSAEK resulted in lower EC loss with comparable cumulative graft survival rates for up to 3 years in patients with Fuchs' dystrophy and BK.
Authors: Xinwen Yao; Kavya Devarajan; René M Werkmeister; Valentin Aranha Dos Santos; Marcus Ang; Anthony Kuo; Damon W K Wong; Jacqueline Chua; Bingyao Tan; Veluchamy Amutha Barathi; Leopold Schmetterer Journal: Biomed Opt Express Date: 2019-10-11 Impact factor: 3.732
Authors: Jonathan H Lass; Beth Ann Benetz; Robin L Gal; Craig Kollman; Dan Raghinaru; Mariya Dontchev; Mark J Mannis; Edward J Holland; Christopher Chow; Kristen McCoy; Francis W Price; Alan Sugar; David D Verdier; Roy W Beck Journal: Ophthalmology Date: 2013-12 Impact factor: 12.079
Authors: Jonathan H Lass; Loretta B Szczotka-Flynn; Allison R Ayala; Beth A Benetz; Robin L Gal; Anthony J Aldave; Michelle M Corrigan; Steven P Dunn; Ty L McCall; Sudeep Pramanik; George O Rosenwasser; Kevin W Ross; Mark A Terry; David D Verdier Journal: Cornea Date: 2015-06 Impact factor: 2.651