Literature DB >> 228849

Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.

M Moriya, T Ohta, K Watanabe, Y Watanabe, F Sugiyama, T Miyazawa, Y Shirasu.   

Abstract

Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM.

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Year:  1979        PMID： 228849     DOI： 10.1016/s0304-3835(79)80061-0

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  2 in total

Review 1.  Pyrazole: preclinical reassessment.

Authors:  P J O'Dwyer; S A King; J Plowman; C K Grieshaber; D F Hoth; B Leyland-Jones
Journal:  Invest New Drugs       Date:  1988-12       Impact factor: 3.850

2.  The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice.

Authors:  P R Kerklaan; S Bouter; J A Zijlstra; G R Mohn
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553
  2 in total

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