| Literature DB >> 22884629 |
Ann Abraham1, Yuesong Wang, Kathleen R El Said, Steven M Plakas.
Abstract
Brevetoxin metabolites were identified and characterized in the hard clam (Mercenaria sp.) after natural exposure to Karenia brevis blooms by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Principal brevetoxins BTX-1 and BTX-2 produced by K. brevis were not detectable in clams. Metabolites of these brevetoxins found in clams included products of oxidation, reduction, hydrolysis and amino acid/fatty acid conjugation. Of highest abundance were cysteine and taurine conjugates. We also found glutathione, glycine-cysteine, and γ-glutamyl-cysteine conjugates. A series of fatty acid derivatives of cysteine-brevetoxin conjugates were also identified. Published by Elsevier Ltd.Entities:
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Year: 2012 PMID： 22884629 DOI： 10.1016/j.toxicon.2012.06.016
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033