Literature DB >> 22884578

New artesunic acid homodimers: potent reversal agents of multidrug resistance in leukemia cells.

Christoph Reiter1, Astrid Herrmann, Aysun Çapci, Thomas Efferth, Svetlana B Tsogoeva.   

Abstract

To evade the problem of multidrug resistance, hybridization of natural products in dimers is considered as an effective method. After the successful synthesis of three artesunic acid homodimers connected by different types of chemical linkers, we analyzed their activity against human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR 5000 leukemia cells and observed, that multidrug resistant cells were not cross-resistant to the new compounds. Collateral sensitivity was observed for artesunic acid homodimer 2. The obtained results deliver valuable information about the linker's structure which is required for homodimers to be highly cytotoxic.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22884578     DOI： 10.1016/j.bmc.2012.07.015

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

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Review 4.  Artemisinin-type drugs for the treatment of hematological malignancies.

Authors:  R I Mancuso; M A Foglio; S T Olalla Saad
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5.  Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity.

Authors:  Jigang Wang; Jianbin Zhang; Yin Shi; Chengchao Xu; Chongjing Zhang; Yin Kwan Wong; Yew Mun Lee; Sanjeev Krishna; Yingke He; Teck Kwang Lim; Weiying Sim; Zi-Chun Hua; Han-Ming Shen; Qingsong Lin
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7.  Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells.

Authors:  Tony Fröhlich; Christoph Reiter; Mohammad M Ibrahim; Jannis Beutel; Corina Hutterer; Isabel Zeitträger; Hanife Bahsi; Maria Leidenberger; Oliver Friedrich; Barbara Kappes; Thomas Efferth; Manfred Marschall; Svetlana B Tsogoeva
Journal:  ACS Omega       Date:  2017-06-01

8.  Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas.

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Review 9.  Antitumor Research on Artemisinin and Its Bioactive Derivatives.

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10.  Synthesis of Tamoxifen-Artemisinin and Estrogen-Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer.

Authors:  Tony Fröhlich; Christina Mai; Roman P Bogautdinov; Svetlana N Morozkina; Alexander G Shavva; Oliver Friedrich; Daniel F Gilbert; Svetlana B Tsogoeva
Journal:  ChemMedChem       Date:  2020-06-30       Impact factor: 3.466
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