Michel Petitjean1, Julie Yeung Lam Ko. 1. Service d'Explorations Fonctionnelles du Système Nerveux, Centre Hospitalier Universitaire d'Amiens, Picardie, France. petitjean.michel@chu-amiens.fr
Abstract
OBJECTIVE: To establish the presence or absence of an age effect on the ipsilateral silent period (iSP) for the abductor pollicis brevis (APB) muscle in healthy subjects. METHODS: Twenty young adults (10 men, 10 women; age range: 20-40) and 20 older adults (10 men, 10 women; age range: 50-70) were matched by age (+30 years), gender and height (±5 cm). All were right-handed. We investigated the iSP for the APB by applying transcranial magnetic stimulation (TMS) and recording surface electromyograms. The contralateral motor-evoked potential (MEP) onset latency, the iSP onset and end latency (iSPOL and iSPEL) were measured and the iSP duration (iSPD) and transcallosal conduction time (TCT) were calculated. We evaluated the correlation between age and iSP, the latter's intra- and intersession reproducibility and potential influencing factors. RESULTS: Mean iSPOL, iSPEL and TCT values were significantly greater in older adults (both men and women) than in young adults. Intra- and intersession reproducibility was good. The mean left-side iSPEL and iSPD were longer than the right-side mean values in young adults but not in older adults. In both age groups, women displayed shorter latencies than men. CONCLUSIONS: There is a strong effect of age on iSP parameters. SIGNIFICANCE: Our iSP results may evidence a decrease in transcallosal excitability with age, rather than slowing of the transcallosal interneuron conduction velocity.
OBJECTIVE: To establish the presence or absence of an age effect on the ipsilateral silent period (iSP) for the abductor pollicis brevis (APB) muscle in healthy subjects. METHODS: Twenty young adults (10 men, 10 women; age range: 20-40) and 20 older adults (10 men, 10 women; age range: 50-70) were matched by age (+30 years), gender and height (±5 cm). All were right-handed. We investigated the iSP for the APB by applying transcranial magnetic stimulation (TMS) and recording surface electromyograms. The contralateral motor-evoked potential (MEP) onset latency, the iSP onset and end latency (iSPOL and iSPEL) were measured and the iSP duration (iSPD) and transcallosal conduction time (TCT) were calculated. We evaluated the correlation between age and iSP, the latter's intra- and intersession reproducibility and potential influencing factors. RESULTS: Mean iSPOL, iSPEL and TCT values were significantly greater in older adults (both men and women) than in young adults. Intra- and intersession reproducibility was good. The mean left-side iSPEL and iSPD were longer than the right-side mean values in young adults but not in older adults. In both age groups, women displayed shorter latencies than men. CONCLUSIONS: There is a strong effect of age on iSP parameters. SIGNIFICANCE: Our iSP results may evidence a decrease in transcallosal excitability with age, rather than slowing of the transcallosal interneuron conduction velocity.
Authors: Martin Schecklmann; Michael Landgrebe; Tobias Kleinjung; Elmar Frank; Rainer Rupprecht; Philipp G Sand; Peter Eichhammer; Göran Hajak; Berthold Langguth Journal: PLoS One Date: 2014-01-07 Impact factor: 3.240
Authors: Keith M McGregor; Bruce Crosson; Kevin Mammino; Javier Omar; Paul S García; Joe R Nocera Journal: Front Aging Neurosci Date: 2018-01-04 Impact factor: 5.750
Authors: Robert Chen; Alfredo Berardelli; Amitabh Bhattacharya; Matteo Bologna; Kai-Hsiang Stanley Chen; Alfonso Fasano; Rick C Helmich; William D Hutchison; Nitish Kamble; Andrea A Kühn; Antonella Macerollo; Wolf-Julian Neumann; Pramod Kumar Pal; Giulia Paparella; Antonio Suppa; Kaviraja Udupa Journal: Clin Neurophysiol Pract Date: 2022-06-30
Authors: Keith M McGregor; Joe R Nocera; Atchar Sudhyadhom; Carolynn Patten; Todd M Manini; Jeffrey A Kleim; Bruce Crosson; Andrew J Butler Journal: Front Aging Neurosci Date: 2013-10-30 Impact factor: 5.750