Literature DB >> 22883228

The mitochondrial pyruvate carrier: has it been unearthed at last?

Andrew P Halestrap1.   

Abstract

The mitochondrial pyruvate carrier (MPC) is essential for several major pathways of carbohydrate, fat, and amino acid metabolism, yet its molecular identity has remained elusive. Two recent papers in Science (Herzig et al., 2012; Bricker et al., 2012) implicate three newly identified inner mitochondrial membrane proteins as MPC components.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22883228     DOI： 10.1016/j.cmet.2012.07.013

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  22 in total

1.  Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.

Authors:  Wing Y Lam; Amy M Becker; Krista M Kennerly; Rachel Wong; Jonathan D Curtis; Elizabeth M Llufrio; Kyle S McCommis; Johannes Fahrmann; Hannah A Pizzato; Ryan M Nunley; Jieun Lee; Michael J Wolfgang; Gary J Patti; Brian N Finck; Erika L Pearce; Deepta Bhattacharya
Journal:  Immunity       Date:  2016-07-05       Impact factor: 31.745

2.  Regulation of substrate utilization by the mitochondrial pyruvate carrier.

Authors:  Nathaniel M Vacanti; Ajit S Divakaruni; Courtney R Green; Seth J Parker; Robert R Henry; Theodore P Ciaraldi; Anne N Murphy; Christian M Metallo
Journal:  Mol Cell       Date:  2014-10-30       Impact factor: 17.970

3.  Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Authors:  Chendong Yang; Bookyung Ko; Christopher T Hensley; Lei Jiang; Ajla T Wasti; Jiyeon Kim; Jessica Sudderth; Maria Antonietta Calvaruso; Lloyd Lumata; Matthew Mitsche; Jared Rutter; Matthew E Merritt; Ralph J DeBerardinis
Journal:  Mol Cell       Date:  2014-10-21       Impact factor: 17.970

4.  Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes.

Authors:  Christopher E Shannon; Giuseppe Daniele; Cynthia Galindo; Muhammad A Abdul-Ghani; Ralph A DeFronzo; Luke Norton
Journal:  FEBS J       Date:  2017-01-18       Impact factor: 5.542

Review 5.  Mitochondrial pyruvate transport: a historical perspective and future research directions.

Authors:  Kyle S McCommis; Brian N Finck
Journal:  Biochem J       Date:  2015-03-15       Impact factor: 3.857

6.  Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Authors:  Nicholas S Heaton; Natasha Moshkina; Romain Fenouil; Thomas J Gardner; Sebastian Aguirre; Priya S Shah; Nan Zhao; Lara Manganaro; Judd F Hultquist; Justine Noel; David Sachs; Jennifer Hamilton; Paul E Leon; Amit Chawdury; Shashank Tripathi; Camilla Melegari; Laura Campisi; Rong Hai; Giorgi Metreveli; Andrea V Gamarnik; Adolfo García-Sastre; Benjamin Greenbaum; Viviana Simon; Ana Fernandez-Sesma; Nevan J Krogan; Lubbertus C F Mulder; Harm van Bakel; Domenico Tortorella; Jack Taunton; Peter Palese; Ivan Marazzi
Journal:  Immunity       Date:  2016-01-19       Impact factor: 31.745

7.  Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells.

Authors:  Alexander A Shestov; Anthony Mancuso; Seung-Cheol Lee; Lili Guo; David S Nelson; Jeffrey C Roman; Pierre-Gilles Henry; Dennis B Leeper; Ian A Blair; Jerry D Glickson
Journal:  J Biol Chem       Date:  2015-12-24       Impact factor: 5.157

8.  The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.

Authors:  Bethany Nancolas; Lili Guo; Rong Zhou; Kavindra Nath; David S Nelson; Dennis B Leeper; Ian A Blair; Jerry D Glickson; Andrew P Halestrap
Journal:  Biochem J       Date:  2016-02-01       Impact factor: 3.857

9.  Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.

Authors:  Ajit S Divakaruni; Sandra E Wiley; George W Rogers; Alexander Y Andreyev; Susanna Petrosyan; Mattias Loviscach; Estelle A Wall; Nagendra Yadava; Alejandro P Heuck; David A Ferrick; Robert R Henry; William G McDonald; Jerry R Colca; Melvin I Simon; Theodore P Ciaraldi; Anne N Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-19       Impact factor: 11.205

10.  C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Authors:  Scott P Allen; Benjamin Hall; Ryan Woof; Laura Francis; Noemi Gatto; Allan C Shaw; Monika Myszczynska; Jordan Hemingway; Ian Coldicott; Amelia Willcock; Lucy Job; Rachel M Hughes; Camilla Boschian; Nadhim Bayatti; Paul R Heath; Oliver Bandmann; Heather Mortiboys; Laura Ferraiuolo; Pamela J Shaw
Journal:  Brain       Date:  2019-12-01       Impact factor: 13.501
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