Jing-fei Zhang1, Wei-yuan Zhang. 1. Affiliated Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Abstract
OBJECTIVE: To explore the potential relationship of cytomegalovirus (CMV), Chlamydia pneumoniae (CP) and herpes simplex virus type 2 (HSV-2) in inflammation and preeclampsia. METHODS: Fifty-two pregnant women with preeclampsia and 34 with uncomplicated pregnancy in the third trimester were recruited. The exclusions included uterine contractions, multiple pregnancies, rupture of membranes, symptomatic infectious diseases, medical diseases and antibiotics or hormones users. Samples of maternal blood were harvested from two groups. Serum levels of CMV, CP, and HSV-2 IgM and IgG antibodies as well as high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA) in preeclampsia and normal pregnancy controls. RESULTS: (1) Recent infections of CMV, CP and HSV-2 were not more common in patients with preeclampsia versus normal pregnancy. The prevalence rates of long-dated CMV, CP and HSV-2 infection were 94.2% (49/52), 53.9% (28/52) and 3.9% (2/52) in preeclampsia group versus 100.0% (34/34), 55.9% (19/34) and 5.9% (2/34) in control group. No significant difference existed between two groups (P > 0.05). (2) Maternal serum concentrations of IL-6 and hs-CRP in patients with preeclampsia were significantly higher than that in normal pregnancy women ((7.2 ± 2.1) ng/L and (6.8 ± 5.6) mg/L vs (6.2 ± 1.8) ng/L and (4.6 ± 3.0) mg/L, both P < 0.05). CONCLUSION: Excessive inflammatory reactions are present in women with preeclampsia. But previous infections, as measured by IgM and IgG antibody seropositivity to CMV, CP and HSV-2, are not correlated with preeclampsia in the third trimester.
OBJECTIVE: To explore the potential relationship of cytomegalovirus (CMV), Chlamydia pneumoniae (CP) and herpes simplex virus type 2 (HSV-2) in inflammation and preeclampsia. METHODS: Fifty-two pregnant women with preeclampsia and 34 with uncomplicated pregnancy in the third trimester were recruited. The exclusions included uterine contractions, multiple pregnancies, rupture of membranes, symptomatic infectious diseases, medical diseases and antibiotics or hormones users. Samples of maternal blood were harvested from two groups. Serum levels of CMV, CP, and HSV-2 IgM and IgG antibodies as well as high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA) in preeclampsia and normal pregnancy controls. RESULTS: (1) Recent infections of CMV, CP and HSV-2 were not more common in patients with preeclampsia versus normal pregnancy. The prevalence rates of long-dated CMV, CP and HSV-2 infection were 94.2% (49/52), 53.9% (28/52) and 3.9% (2/52) in preeclampsia group versus 100.0% (34/34), 55.9% (19/34) and 5.9% (2/34) in control group. No significant difference existed between two groups (P > 0.05). (2) Maternal serum concentrations of IL-6 and hs-CRP in patients with preeclampsia were significantly higher than that in normal pregnancy women ((7.2 ± 2.1) ng/L and (6.8 ± 5.6) mg/L vs (6.2 ± 1.8) ng/L and (4.6 ± 3.0) mg/L, both P < 0.05). CONCLUSION: Excessive inflammatory reactions are present in women with preeclampsia. But previous infections, as measured by IgM and IgG antibody seropositivity to CMV, CP and HSV-2, are not correlated with preeclampsia in the third trimester.
Authors: Cosme Alvarado-Esquivel; Ada A Sandoval-Carrillo; Fernando Vazquez-Alaniz; José M Salas-Pacheco; Jesús Hernández-Tinoco; Luis Francisco Sánchez-Anguiano; Elizabeth Irasema Antuna-Salcido Journal: Eur J Microbiol Immunol (Bp) Date: 2017-07-13
Authors: Cosme Alvarado-Esquivel; Fernando Vázquez-Alaníz; Ada A Sandoval-Carrillo; José M Salas-Pacheco; Jesús Hernández-Tinoco; Luis Francisco Sánchez-Anguiano; Oliver Liesenfeld Journal: Parasit Vectors Date: 2014-04-03 Impact factor: 3.876