| Literature DB >> 22879002 |
Hélène Lazareth1, Gilles Peytavin, Laura Polivka, Nicolas Dupin.
Abstract
Levamisole-induced vasculitis is a well-characterised antineutrophil cytoplasm antibodies (ANCA)-positive vasculitis in cocaine abuser patients. However, due to the short half-life of levamisole in serum and urine, the causal role of levamisole is not established. Here we report the detection of both levamisole and cocaine in hair samples of a patient who presented with an ANCA-positive vasculitis. The higher concentration of levamisole in proximal sample of the hair confirms that the patient abused of cocaine added with levamisole in the days preceding the development of skin lesions. Although a direct causative role has not been established, our report strongly suggests that levamisole may have triggered vasculitis in this case.Entities:
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Year: 2012 PMID: 22879002 PMCID: PMC4544026 DOI: 10.1136/bcr-2012-006602
Source DB: PubMed Journal: BMJ Case Rep ISSN: 1757-790X