| Literature DB >> 22878199 |
Menglei Huan1, Han Cui, Zenghui Teng, Bangle Zhang, Jieping Wang, Xinyou Liu, Hui Xia, Siyuan Zhou, Qibing Mei.
Abstract
The conventional chemotherapy agent, doxorubicin, is of limited clinical use because of its systemic toxicity toward normal healthy tissue. A new doxorubicin conjugate with α-linolenic acid showed good anti-tumor activity with lower toxicity than free doxorubicin and exhibited an active tumor-targeting profile due to the introduction of α-linolenic acid which might be an effective tumor-targeting moiety for the modification of chemotherapeutics.Entities:
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Year: 2012 PMID： 22878199 DOI： 10.1271/bbb.120256
Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN： 0916-8451 Impact factor: 2.043