OBJECTIVE: To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia. METHODS: Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay. RESULTS: One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease. CONCLUSION: Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
OBJECTIVE: To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia. METHODS: Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenicpatients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay. RESULTS: One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease. CONCLUSION: Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
Authors: Regina F Nasyrova; Polina V Moskaleva; Elena E Vaiman; Natalya A Shnayder; Nataliya L Blatt; Albert A Rizvanov Journal: Int J Mol Sci Date: 2020-02-26 Impact factor: 5.923