| Literature DB >> 22873794 |
Shuntaro Ushiyama1, Hideharu Umaoka, Hikaru Kato, Yoshiaki Suwa, Hiroshi Morioka, Henki Rotinsulu, Fitje Losung, Remy E P Mangindaan, Nicole J de Voogd, Hideyoshi Yokosawa, Sachiko Tsukamoto.
Abstract
Two new dimeric sterols, manadosterols A (1) and B (2), were isolated from the marine sponge Lissodendryx fibrosa collected in Indonesia. The two compounds are comprised of two sulfonated sterol cores connected through the respective side chains. Manadosterols A (1) and B (2) inhibited the Ubc13-Uev1A interaction with IC(50) values of 0.09 and 0.13 μM, respectively. They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22873794 DOI： 10.1021/np300352u
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050