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Literature DB >> 22873178

The Rabs: a family at the root of metazoan evolution.

Abstract

Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit specific regulators of membrane traffic. Two recent papers, including one by Klöpper et al. in BMC Biology, present phylogenomic evidence that the Rab repertoire was established very early in eukaryotic evolution, and correlates with interspecies variations in organelles.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
rab GTP-Binding Proteins

Year: 2012 PMID： 22873178 PMCID： PMC3414739 DOI： 10.1186/1741-7007-10-68

Source DB: PubMed Journal: BMC Biol ISSN： 1741-7007 Impact factor: 7.431

10 in total

Review 1. Rab proteins as membrane organizers.

Authors: M Zerial; H McBride
Journal: Nat Rev Mol Cell Biol Date: 2001-02 Impact factor: 94.444

2. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.

Authors: J B Pereira-Leal; M C Seabra
Journal: J Mol Biol Date: 2000-08-25 Impact factor: 5.469

3. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.

Authors: C Bucci; R G Parton; I H Mather; H Stunnenberg; K Simons; B Hoflack; M Zerial
Journal: Cell Date: 1992-09-04 Impact factor: 41.582

4. Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases.

Authors: Marek Elias; Andrew Brighouse; Carme Gabernet-Castello; Mark C Field; Joel B Dacks
Journal: J Cell Sci Date: 2012-02-24 Impact factor: 5.285

5. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.

Authors: P Chavrier; R G Parton; H P Hauri; K Simons; M Zerial
Journal: Cell Date: 1990-07-27 Impact factor: 41.582

Review 6. Rab GTPases as coordinators of vesicle traffic.

Authors: Harald Stenmark
Journal: Nat Rev Mol Cell Biol Date: 2009-07-15 Impact factor: 94.444

7. A ras-like protein is required for a post-Golgi event in yeast secretion.

Authors: A Salminen; P J Novick
Journal: Cell Date: 1987-05-22 Impact factor: 41.582

8. Evolution of the Rab family of small GTP-binding proteins.

Authors: J B Pereira-Leal; M C Seabra
Journal: J Mol Biol Date: 2001-11-02 Impact factor: 5.469

Review 9. Patterns and processes in the evolution of the eukaryotic endomembrane system.

Authors: Marek Elias
Journal: Mol Membr Biol Date: 2010-11-11 Impact factor: 2.857

10. Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis.

Authors: Tobias H Klöpper; Nickias Kienle; Dirk Fasshauer; Sean Munro
Journal: BMC Biol Date: 2012-08-08 Impact factor: 7.431

10 in total

5 in total

5. Site-directed mutagenesis, in vivo electroporation and mass spectrometry in search for determinants of the subcellular targeting of Rab7b paralogue in the model eukaryote Paramecium octaurelia.

Authors: E Wyroba; P Kwaśniak; K Miller; K Kobyłecki; M Osińska
Journal: Eur J Histochem Date: 2016-04-11 Impact factor: 3.188