| Literature DB >> 22871581 |
Bieong-Kil Kim1, Hyungu Kang, Kyung-Oh Doh, Seong-Hye Lee, Jong-Won Park, Su-Jin Lee, Tae-Jin Lee.
Abstract
Recently, cysteine residue incorporation increased liposome-mediated transfection compared to unmodified peptide. Therefore, we designed novel modified SV40 NLS peptides, homodimeric (NLS-CTHD, NLS-NTHD) and closed structure (cyclic NLS), simply using disulfide bond between cysteines to develop more efficient and safe non-viral gene delivery system. The simple mix of NLS-CTHD among these novel transfection enhancing peptides with DNA increased the gene transfer potency of cationic liposomes more efficiently with no additional cytotoxicity.Entities:
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Year: 2012 PMID： 22871581 DOI： 10.1016/j.bmcl.2012.07.051
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823