| Literature DB >> 22871433 |
Daniel L Yokell1, Alicia K Leece, Artem Lebedev, Reza Miraghaie, Carroll E Ball, Jianzhong Zhang, Hartmuth Kolb, Arkadij Elizarov, Umar Mahmood.
Abstract
We report an automated synthesis of [(18)F]-FMISO utilizing a prototype microfluidic radiochemistry module. The instrument allows for production of the tracer with 58%±2% (11 runs) decay corrected yield. Total time of production, including synthesis and purification averages 60 min. Use of the microfluidic platform results in a specific activity of 138.6 GBq/μ mol, which is higher than previously reported for conventional reactors.Entities:
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Year: 2012 PMID： 22871433 PMCID： PMC3753664 DOI： 10.1016/j.apradiso.2012.05.022
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513