Literature DB >> 22867699

Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias.

Eric Q Wei1, Adam S Barnett, Geoffrey S Pitt, Jessica A Hennessey.   

Abstract

The four fibroblast growth factor homologous factors (FHFs; FGF11-FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs). Although FHFs have been well studied in neurons and implicated in neurologic disease, their role in cardiomyocytes was unclear until recently. This review discusses the expression profile and function of FHFs in mouse and rat ventricular cardiomyocytes. Recent data show that FGF13 is the predominant FHF in the murine heart, directly binds the cardiac VGSC α subunit, and is essential for normal cardiac conduction. FHF loss-of-function mutations may be unrecognized causes of cardiac arrhythmias, such as long QT and Brugada syndromes.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22867699      PMCID： PMC3413878          DOI： 10.1016/j.tcm.2012.05.010

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  32 in total

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Authors:  S D Dib-Hajj; S G Waxman
Journal:  J Biol Chem       Date:  2001-03-16       Impact factor: 5.157

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Authors:  Guy Lemaillet; Barbara Walker; Stephen Lambert
Journal:  J Biol Chem       Date:  2003-04-25       Impact factor: 5.157

3.  Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

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Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

4.  A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar ataxia [corrected].

Authors:  John C van Swieten; Esther Brusse; Bianca M de Graaf; Elmar Krieger; Raoul van de Graaf; Inge de Koning; Anneke Maat-Kievit; Peter Leegwater; Dennis Dooijes; Ben A Oostra; Peter Heutink
Journal:  Am J Hum Genet       Date:  2002-12-13       Impact factor: 11.025

5.  Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B.

Authors:  Chuan-ju Liu; Sulayman D Dib-Hajj; Muthukrishnan Renganathan; Theodore R Cummins; Stephen G Waxman
Journal:  J Biol Chem       Date:  2002-10-24       Impact factor: 5.157

6.  Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing.

Authors:  I Munoz-Sanjuan; P M Smallwood; J Nathans
Journal:  J Biol Chem       Date:  2000-01-28       Impact factor: 5.157

7.  Identification of a new SCN5A mutation, D1840G, associated with the long QT syndrome. Mutations in brief no. 153. Online.

Authors:  J Benhorin; M Goldmit; J W MacCluer; J Blangero; R Goffen; A Leibovitch; A Rahat; Q Wang; A Medina; J Towbin; B Kerem
Journal:  Hum Mutat       Date:  1998       Impact factor: 4.878

8.  Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient.

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Journal:  Hum Genet       Date:  1999-01       Impact factor: 4.132

9.  Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits.

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Journal:  Circ Res       Date:  1998-07-27       Impact factor: 17.367

10.  SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome.

Authors:  Q Wang; J Shen; I Splawski; D Atkinson; Z Li; J L Robinson; A J Moss; J A Towbin; M T Keating
Journal:  Cell       Date:  1995-03-10       Impact factor: 41.582
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  7 in total

1.  The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).

Authors:  Alexander S Shavkunov; Norelle C Wildburger; Miroslav N Nenov; Thomas F James; Tetyana P Buzhdygan; Neli I Panova-Elektronova; Thomas A Green; Ronald L Veselenak; Nigel Bourne; Fernanda Laezza
Journal:  J Biol Chem       Date:  2013-05-02       Impact factor: 5.157

2.  FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.

Authors:  Jing Yang; Zhihua Wang; Daniel S Sinden; Xiangchong Wang; Bin Shan; Xiao Yu; Hailin Zhang; Geoffrey S Pitt; Chuan Wang
Journal:  Channels (Austin)       Date:  2016-05-31       Impact factor: 2.581

3.  Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.

Authors:  Jacqueline Niu; Ivy E Dick; Wanjun Yang; Moradeke A Bamgboye; David T Yue; Gordon Tomaselli; Takanari Inoue; Manu Ben-Johny
Journal:  Elife       Date:  2018-09-10       Impact factor: 8.140

4.  Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.

Authors:  Xiangchong Wang; He Tang; Eric Q Wei; Zhihua Wang; Jing Yang; Rong Yang; Sheng Wang; Yongjian Zhang; Geoffrey S Pitt; Hailin Zhang; Chuan Wang
Journal:  J Mol Cell Cardiol       Date:  2017-01-21       Impact factor: 5.000

5.  Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current.

Authors:  Nourdine Chakouri; Sharen Rivas; Daniel Roybal; Lin Yang; Johanna Diaz; Allen Hsu; Ryan Mahling; Bi-Xing Chen; Josiah O Owoyemi; Deborah DiSilvestre; Dario Sirabella; Barbara Corneo; Gordon F Tomaselli; Ivy E Dick; Steven O Marx; Manu Ben-Johny
Journal:  Nat Cardiovasc Res       Date:  2022-05-16

6.  FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.

Authors:  Martyna Sochacka; Lukasz Opalinski; Jakub Szymczyk; Marta B Zimoch; Aleksandra Czyrek; Daniel Krowarsch; Jacek Otlewski; Malgorzata Zakrzewska
Journal:  Cell Commun Signal       Date:  2020-05-01       Impact factor: 5.712

7.  Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice.

Authors:  Wei-Hua Jia; Nuo-Qi Wang; Lin Yin; Xi Chen; Bi-Yu Hou; Jin-Hua Wang; Gui-Fen Qiang; Chi Bun Chan; Xiu-Ying Yang; Guan-Hua Du
Journal:  Biol Sex Differ       Date:  2020-03-10       Impact factor: 5.027
  7 in total

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