Literature DB >> 22867097

Inhibition of human topoisomerases I and II by simocyclinone D8.

Lisa M Oppegard1, Thuy Nguyen, Keith C Ellis, Hiroshi Hiasa.   

Abstract

Simocyclinone D8 is an antibiotic isolated from Streptomyces antibioticus Tü 6040 that inhibits the supercoiling activity of DNA gyrase. It also exhibits an inhibitory effect on human topoisomerase II and an antiproliferative activity against some cancer cell lines. Our biochemical studies have revealed that simocyclinone D8 can inhibit the catalytic activity of human topoisomerase I. Thus, simocyclinone D8 is a dual catalytic inhibitor of human topoisomerases I and II.

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Year:  2012        PMID： 22867097     DOI： 10.1021/np300299y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.

Authors:  Lisa M Oppegard; Justine L Delgado; Chaitanya A Kulkarni; Tyrell R Towle; Delaney E Hart; Bridget P Williams; Sarah R C Lentz; Beverly J Norris; Craig M Flory; Robert J Schumacher; Daryl J Murry; Robert J Kerns; Hiroshi Hiasa
Journal:  Invest New Drugs       Date:  2018-09-10       Impact factor: 3.850

Review 2.  Topoisomerases as anticancer targets.

Authors:  Justine L Delgado; Chao-Ming Hsieh; Nei-Li Chan; Hiroshi Hiasa
Journal:  Biochem J       Date:  2018-01-23       Impact factor: 3.857

3.  Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.

Authors:  Justine L Delgado; Sarah R C Lentz; Chaitanya A Kulkarni; Pratik R Chheda; Hailey A Held; Hiroshi Hiasa; Robert J Kerns
Journal:  Eur J Med Chem       Date:  2019-03-20       Impact factor: 6.514
  3 in total

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