| Literature DB >> 22864254 |
Tatiana Flisikowska1, Claudia Merkl1, Martina Landmann1, Stefan Eser2, Nousin Rezaei1, Xinxin Cui1, Mayuko Kurome3, Valeri Zakhartchenko3, Barbara Kessler3, Hagen Wieland1, Oswald Rottmann1, Roland M Schmid2, Günter Schneider2, Alexander Kind1, Eckhard Wolf3, Dieter Saur2, Angelika Schnieke4.
Abstract
We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.Entities:
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Year: 2012 PMID： 22864254 DOI： 10.1053/j.gastro.2012.07.110
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682