| Literature DB >> 22864134 |
Abstract
A dipeptidyl peptidase (DPP)-4 inhibitor, commonly used to treat patients with type 2 diabetes, has caused concern because of immune system side effects. We report a 48-year-old woman with type 2 diabetes who was diagnosed with rheumatoid arthritis (RA) after continued polyarthritis and an increase in rheumatoid factor up to 86 IU/mL after three months of treatment with sitagliptin, a DPP-4 inhibitor. The shared epitope (SE)-containing human leukocyte antigen (HLA)-DRB1 alleles, which are important predisposing factors for RA, were positive. RA might have been triggered by sitagliptin due to a predisposing condition.Entities:
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Year: 2012 PMID： 22864134 DOI： 10.2169/internalmedicine.51.7592
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271