Literature DB >> 2286401

Pediatric neuro-oncology: controversies in current therapy.

M T Jennings1.   

Abstract

Current Phase III clinical trials for the treatment of malignant central nervous system (CNS) tumors of childhood are reviewed. Combination neurosurgical, radiation treatment and chemotherapy have improved both the quality and duration of life for the affected children. Controversy exists regarding the appropriate adjunctive chemotherapy for newly diagnosed CNS neoplasms but this is being prospectively studied in controlled trials. Major dilemmas persist regarding the management of low-grade gliomas and recurrent CNS neoplasms. Preliminary data on possibly favourable protocols are cited. Future directions for clinical and basic laboratory investigation are also briefly reviewed.

Entities:  

Mesh：

Year:  1990        PMID： 2286401     DOI： 10.1007/bf02726754

Source DB:  PubMed          Journal:  Indian J Pediatr        ISSN： 0019-5456            Impact factor:   1.967


  19 in total

1.  The role of radiation therapy in the treatment of astrocytomas.

Authors:  S A Leibel; G E Sheline; W M Wara; E B Boldrey; S L Nielsen
Journal:  Cancer       Date:  1975-06       Impact factor: 6.860

2.  Prognostic factors in well-differentiated cerebral astrocytomas in the adult.

Authors:  R Soffietti; A Chiò; M T Giordana; E Vasario; D Schiffer
Journal:  Neurosurgery       Date:  1989-05       Impact factor: 4.654

3.  Radiation therapy in the management of low-grade supratentorial astrocytomas.

Authors:  E G Shaw; C Daumas-Duport; B W Scheithauer; D T Gilbertson; J R O'Fallon; J D Earle; E R Laws; H Okazaki
Journal:  J Neurosurg       Date:  1989-06       Impact factor: 5.115

4.  Prospective randomized cooperative medulloblastoma trial (MED 84) of the International Society of Paediatric Oncology (SIOP) and of the (German) Society of Paediatric Oncology (GPO).

Authors:  M K Neidhardt; C C Bailey
Journal:  Childs Nerv Syst       Date:  1987       Impact factor: 1.475

Review 5.  Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980.

Authors:  H J Bloom
Journal:  Int J Radiat Oncol Biol Phys       Date:  1982-07       Impact factor: 7.038

6.  Results of radiation treatment of cerebellar medulloblastoma.

Authors:  H W Chin; Y Maruyama
Journal:  Int J Radiat Oncol Biol Phys       Date:  1981-06       Impact factor: 7.038

7.  The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group.

Authors:  R Sposto; I J Ertel; R D Jenkin; C P Boesel; J L Venes; J A Ortega; A E Evans; W Wara; D Hammond
Journal:  J Neurooncol       Date:  1989-07       Impact factor: 4.130

8.  Supratentorial malignant gliomas of childhood. Results of treatment with radiation therapy and chemotherapy.

Authors:  S Phuphanich; M S Edwards; V A Levin; P S Vestnys; W M Wara; R L Davis; C B Wilson
Journal:  J Neurosurg       Date:  1984-03       Impact factor: 5.115

9.  Brain-stem tumors in childhood: a prospective randomized trial of irradiation with and without adjuvant CCNU, VCR, and prednisone. A report of the Childrens Cancer Study Group.

Authors:  R D Jenkin; C Boesel; I Ertel; A Evans; R Hittle; J Ortega; R Sposto; W Wara; C Wilson; J Anderson
Journal:  J Neurosurg       Date:  1987-02       Impact factor: 5.115

10.  High-dose cyclophosphamide chemotherapy for recurrent CNS tumors in children.

Authors:  J C Allen; L Helson
Journal:  J Neurosurg       Date:  1981-11       Impact factor: 5.115
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