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Literature DB >> 22863881

A mouse model to identify cooperating signaling pathways in cancer.

Monica Musteanu¹, Leander Blaas, Rainer Zenz, Jasmin Svinka, Thomas Hoffmann, Beatrice Grabner, Daniel Schramek, Hans-Peter Kantner, Mathias Müller, Thomas Kolbe, Thomas Rülicke, Richard Moriggl, Lukas Kenner, Dagmar Stoiber, Josef Martin Penninger, Helmut Popper, Emilio Casanova, Robert Eferl.

Abstract

We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22863881 DOI： 10.1038/nmeth.2130

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

23 in total

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Authors: Stephen A Chappell; Gerald M Edelman; Vincent P Mauro
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2. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.

Authors: Konrad Hochedlinger; Yasuhiro Yamada; Caroline Beard; Rudolf Jaenisch
Journal: Cell Date: 2005-05-06 Impact factor: 41.582

3. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

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Journal: Cell Date: 2007-06-01 Impact factor: 41.582

Review 4. Cancer therapy based on oncogene addiction.

Authors: Frank McCormick
Journal: J Surg Oncol Date: 2011-05-01 Impact factor: 3.454

5. T cell-specific loss of Pten leads to defects in central and peripheral tolerance.

Authors: A Suzuki; M T Yamaguchi; T Ohteki; T Sasaki; T Kaisho; Y Kimura; R Yoshida; A Wakeham; T Higuchi; M Fukumoto; T Tsubata; P S Ohashi; S Koyasu; J M Penninger; T Nakano; T W Mak
Journal: Immunity Date: 2001-05 Impact factor: 31.745

6. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin.

Authors: V Vasioukhin; L Degenstein; B Wise; E Fuchs
Journal: Proc Natl Acad Sci U S A Date: 1999-07-20 Impact factor: 11.205

7. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

Authors: Ulrik Doehn; Camilla Hauge; Scott R Frank; Claus J Jensen; Katarzyna Duda; Jakob V Nielsen; Michael S Cohen; Jens V Johansen; Benny R Winther; Leif R Lund; Ole Winther; Jack Taunton; Steen H Hansen; Morten Frödin
Journal: Mol Cell Date: 2009-08-28 Impact factor: 17.970

8. Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues.

Authors: Dorothe Hameyer; Ate Loonstra; Leonid Eshkind; Steffen Schmitt; Cecilia Antunes; Annemiek Groen; Eric Bindels; Jos Jonkers; Paul Krimpenfort; Ralph Meuwissen; Loes Rijswijk; Axel Bex; Anton Berns; Ernesto Bockamp
Journal: Physiol Genomics Date: 2007-04-24 Impact factor: 3.107

9. A new logic for DNA engineering using recombination in Escherichia coli.

Authors: Y Zhang; F Buchholz; J P Muyrers; A F Stewart
Journal: Nat Genet Date: 1998-10 Impact factor: 38.330

Review 10. Hallmarks of cancer: the next generation.

Authors: Douglas Hanahan; Robert A Weinberg
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

4 in total

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