Füsun Sahin1, Pinar Yildiz. 1. Department of Pulmonology, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey. fusunsahin19700@hotmail.com
Abstract
PURPOSE: CA-125 is a high molecular weight mucin-like glycoprotein and an ovarian cancer antigen. Elevated CA-125 levels are also seen with various other benign and malignant conditions. In this study, the ability of CA-125 to predict pulmonary tuberculosis activity was investigated. METHODS: This analytical study included 42 cases with active tuberculosis (Group 1), 35 cases with inactive tuberculosis (Group 2) and 20 healthy subjects (Group 3). CA-125 measurements were taken in all three groups. Measurements in Group 1 were repeated after completing a two month anti-tuberculosis treatment in 38 of the 42 patients. RESULTS: Mean serum CA-125 level for Group 1 was 76.48 ± 24.71 U/mL, which was significantly higher than levels in Group 2 (20.01 ± 7.89 U/mL) and Group 3 (18.32 ± 2.87 U/mL) (p < 0.001). Of the 38 patients in Group 1 who were studied both pre- and post-treatment, CA-125 levels decreased significantly: from 78.88 ± 24.72 U/mL before treatment to 22.78 ± 8.02 U/mL after treatment (p < 0.001). There was no statistically significant difference between the post-treatment values of Group 1 and either Group 2 and Group 3 values (p > 0.05). Group 2 and Group 3 levels were not significantly different (p > 0.05). The cut-off level for accurate determination of activity was 36.35 U/mL. The sensitivity at this level was 97.6% and specificity was 100%. CONCLUSION: Our findings suggest that CA-125 can be a beneficial parameter in determination of pulmonary tuberculosis activity and the evaluation of response to treatment.
PURPOSE:CA-125 is a high molecular weight mucin-like glycoprotein and an ovarian cancer antigen. Elevated CA-125 levels are also seen with various other benign and malignant conditions. In this study, the ability of CA-125 to predict pulmonary tuberculosis activity was investigated. METHODS: This analytical study included 42 cases with active tuberculosis (Group 1), 35 cases with inactive tuberculosis (Group 2) and 20 healthy subjects (Group 3). CA-125 measurements were taken in all three groups. Measurements in Group 1 were repeated after completing a two month anti-tuberculosis treatment in 38 of the 42 patients. RESULTS: Mean serum CA-125 level for Group 1 was 76.48 ± 24.71 U/mL, which was significantly higher than levels in Group 2 (20.01 ± 7.89 U/mL) and Group 3 (18.32 ± 2.87 U/mL) (p < 0.001). Of the 38 patients in Group 1 who were studied both pre- and post-treatment, CA-125 levels decreased significantly: from 78.88 ± 24.72 U/mL before treatment to 22.78 ± 8.02 U/mL after treatment (p < 0.001). There was no statistically significant difference between the post-treatment values of Group 1 and either Group 2 and Group 3 values (p > 0.05). Group 2 and Group 3 levels were not significantly different (p > 0.05). The cut-off level for accurate determination of activity was 36.35 U/mL. The sensitivity at this level was 97.6% and specificity was 100%. CONCLUSION: Our findings suggest that CA-125 can be a beneficial parameter in determination of pulmonary tuberculosis activity and the evaluation of response to treatment.
Authors: Payam Nahid; Erin Bliven-Sizemore; Leah G Jarlsberg; Mary A De Groote; John L Johnson; Grace Muzanyi; Melissa Engle; Marc Weiner; Nebojsa Janjic; David G Sterling; Urs A Ochsner Journal: Tuberculosis (Edinb) Date: 2014-02-07 Impact factor: 3.131
Authors: Longxiang Xie; Xiaoyu Chao; Tieshan Teng; Qiming Li; Jianping Xie Journal: Int J Environ Res Public Health Date: 2020-09-24 Impact factor: 3.390