OBJECTIVE: Neurofilament (NF) is a major cytoskeletal protein of neurons. Elevation of serum NF concentration suggests neuronal injury, especially damage to axons. We assessed neuronal damage in febrile seizure (FS) by using NF. METHODS: We used enzyme-linked immunosorbent assay to measure serum levels of the phosphorylated form of NF-heavy chain (pNF-H) in 42 children with FS and 28 controls. RESULTS: Serum pNF-H levels in children with prolonged febrile seizure (PFS) (n=29) were significantly higher than those in the controls (p<0.001). There were no significant differences in serum pNF-H levels between children with simple febrile seizure (n=9) and the controls. There was a significant correlation between seizure duration and serum pNF-H levels during the first week in children with FS (p=0.022, r=0.37). CONCLUSION: Our results suggest that PFS could lead to some degree of neuronal damage even in the absence of abnormal clinical neurological findings during the short-term follow up period.
OBJECTIVE: Neurofilament (NF) is a major cytoskeletal protein of neurons. Elevation of serum NF concentration suggests neuronal injury, especially damage to axons. We assessed neuronal damage in febrile seizure (FS) by using NF. METHODS: We used enzyme-linked immunosorbent assay to measure serum levels of the phosphorylated form of NF-heavy chain (pNF-H) in 42 children with FS and 28 controls. RESULTS: Serum pNF-H levels in children with prolonged febrile seizure (PFS) (n=29) were significantly higher than those in the controls (p<0.001). There were no significant differences in serum pNF-H levels between children with simple febrile seizure (n=9) and the controls. There was a significant correlation between seizure duration and serum pNF-H levels during the first week in children with FS (p=0.022, r=0.37). CONCLUSION: Our results suggest that PFS could lead to some degree of neuronal damage even in the absence of abnormal clinical neurological findings during the short-term follow up period.
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Authors: Antoinette Depoorter; Roland P Neumann; Christian Barro; Urs Fisch; Peter Weber; Jens Kuhle; Sven Wellmann Journal: Front Neurol Date: 2018-11-20 Impact factor: 4.003
Authors: Basil T Darras; Thomas O Crawford; Richard S Finkel; Eugenio Mercuri; Darryl C De Vivo; Maryam Oskoui; Eduardo F Tizzano; Monique M Ryan; Francesco Muntoni; Guolin Zhao; John Staropoli; Alexander McCampbell; Marco Petrillo; Christopher Stebbins; Stephanie Fradette; Wildon Farwell; Charlotte J Sumner Journal: Ann Clin Transl Neurol Date: 2019-04-17 Impact factor: 4.511
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