Literature DB >> 22862942

How can human pluripotent stem cells help decipher and cure Huntington's disease?

Anselme Perrier1, Marc Peschanski.   

Abstract

Pluripotent stem cell (PSC) technologies are becoming a key asset for deciphering pathological cascades and for developing new treatments against many neurodegenerative disorders, including Huntington's disease (HD). This perspective discusses the challenges and opportunities facing the use of PSCs for treating HD, focusing on four major applications: namely, the use of PSCs as a substitute source of human striatal cells for current HD cell therapy, as a cellular model of HD for the validation of human-specific gene therapies, for deciphering molecular mechanisms underlying HD, and in drug discovery.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22862942     DOI： 10.1016/j.stem.2012.07.015

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

Review 1.  Progress and prospects for genetic modification of nonhuman primate models in biomedical research.

Authors:  Anthony W S Chan
Journal:  ILAR J       Date:  2013

Review 2.  Induced Pluripotent Stem Cells in Huntington's Disease: Disease Modeling and the Potential for Cell-Based Therapy.

Authors:  Ling Liu; Jin-Sha Huang; Chao Han; Guo-Xin Zhang; Xiao-Yun Xu; Yan Shen; Jie Li; Hai-Yang Jiang; Zhi-Cheng Lin; Nian Xiong; Tao Wang
Journal:  Mol Neurobiol       Date:  2015-12-10       Impact factor: 5.590

Review 3.  Pluripotent stem cells in regenerative medicine: challenges and recent progress.

Authors:  Viviane Tabar; Lorenz Studer
Journal:  Nat Rev Genet       Date:  2014-02       Impact factor: 53.242

Review 4.  Use of human pluripotent stem cells to study and treat retinopathies.

Authors:  Karim Ben M'Barek; Florian Regent; Christelle Monville
Journal:  World J Stem Cells       Date:  2015-04-26       Impact factor: 5.326

5.  Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease.

Authors:  Kittiphong Putkhao; Jannet Kocerha; In-Ki Cho; Jinjing Yang; Rangsun Parnpai; Anthony W S Chan
Journal:  Stem Cells Dev       Date:  2013-01-15       Impact factor: 3.272

Review 6.  Using human induced pluripotent stem cells to model cerebellar disease: hope and hype.

Authors:  Sarah Wiethoff; Charles Arber; Abi Li; Selina Wray; Henry Houlden; Rickie Patani
Journal:  J Neurogenet       Date:  2015-08-27       Impact factor: 1.250

7.  Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells.

Authors:  Richard L Carter; Yiju Chen; Tanut Kunkanjanawan; Yan Xu; Sean P Moran; Kittiphong Putkhao; Jinjing Yang; Anderson H C Huang; Rangsun Parnpai; Anthony W S Chan
Journal:  Stem Cell Reports       Date:  2014-09-04       Impact factor: 7.765

8.  Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.

Authors:  Karine Cambon; Virginie Zimmer; Sylvain Martineau; Marie-Claude Gaillard; Margot Jarrige; Aurore Bugi; Jana Miniarikova; Maria Rey; Raymonde Hassig; Noelle Dufour; Gwenaelle Auregan; Philippe Hantraye; Anselme L Perrier; Nicole Déglon
Journal:  Mol Ther Methods Clin Dev       Date:  2017-05-11       Impact factor: 6.698

Review 9.  Human pluripotent stem cells for modelling human liver diseases and cell therapy.

Authors:  Noushin Dianat; Clara Steichen; Ludovic Vallier; Anne Weber; Anne Dubart-Kupperschmitt
Journal:  Curr Gene Ther       Date:  2013-04       Impact factor: 4.391

Review 10.  Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury.

Authors:  Vanessa M Doulames; Giles W Plant
Journal:  Int J Mol Sci       Date:  2016-04-09       Impact factor: 5.923
  10 in total

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