OBJECTIVES: To investigate whether higher intake of potassium, calcium, and magnesium reduces the risk of incident dementia. DESIGN: Prospective cohort study. SETTING: The Hisayama Study, in Japan. PARTICIPANTS: One thousand eighty-one community-dwelling Japanese individuals without dementia aged 60 and older. MEASUREMENTS: A 70-item semiquantitative food frequency questionnaire was used to assess potassium, calcium, and magnesium intakes. Hazard ratios (HRs) for the development of all-cause dementia and its subtypes were estimated using Cox proportional hazards model. RESULTS: During a 17-year follow-up, 303 participants experienced all-cause dementia; of these, 98 had vascular dementia (VaD), and 166 had Alzheimer's disease (AD). The multivariable-adjusted HRs for the development of all-cause dementia were 0.52 (95% confidence interval [CI] = 0.30-0.91), 0.64 (95% CI = 0.41-1.00), and 0.63 (95% CI = 0.40-1.01) for the highest quartiles of potassium, calcium, and magnesium intake, respectively, compared with the corresponding lowest quartiles. Similarly, the HRs for the development of VaD were 0.20 (95% CI = 0.07-0.56), 0.24 (95% CI = 0.11-0.53), and 0.26 (95% CI = 0.11-0.61) for the highest quartiles of potassium, calcium, and magnesium intake, respectively. There was no evidence of a linear association between these mineral intakes and the risk of AD. CONCLUSION: Higher self-reported dietary intakes of potassium, calcium, and magnesium reduce the risk of all-cause dementia, especially VaD, in the general Japanese population.
OBJECTIVES: To investigate whether higher intake of potassium, calcium, and magnesium reduces the risk of incident dementia. DESIGN: Prospective cohort study. SETTING: The Hisayama Study, in Japan. PARTICIPANTS: One thousand eighty-one community-dwelling Japanese individuals without dementia aged 60 and older. MEASUREMENTS: A 70-item semiquantitative food frequency questionnaire was used to assess potassium, calcium, and magnesium intakes. Hazard ratios (HRs) for the development of all-cause dementia and its subtypes were estimated using Cox proportional hazards model. RESULTS: During a 17-year follow-up, 303 participants experienced all-cause dementia; of these, 98 had vascular dementia (VaD), and 166 had Alzheimer's disease (AD). The multivariable-adjusted HRs for the development of all-cause dementia were 0.52 (95% confidence interval [CI] = 0.30-0.91), 0.64 (95% CI = 0.41-1.00), and 0.63 (95% CI = 0.40-1.01) for the highest quartiles of potassium, calcium, and magnesium intake, respectively, compared with the corresponding lowest quartiles. Similarly, the HRs for the development of VaD were 0.20 (95% CI = 0.07-0.56), 0.24 (95% CI = 0.11-0.53), and 0.26 (95% CI = 0.11-0.61) for the highest quartiles of potassium, calcium, and magnesium intake, respectively. There was no evidence of a linear association between these mineral intakes and the risk of AD. CONCLUSION: Higher self-reported dietary intakes of potassium, calcium, and magnesium reduce the risk of all-cause dementia, especially VaD, in the general Japanese population.
Authors: Vittorio Dibello; Frank Lobbezoo; Madia Lozupone; Rodolfo Sardone; Andrea Ballini; Giuseppe Berardino; Anita Mollica; Hélio José Coelho-Júnior; Giovanni De Pergola; Roberta Stallone; Antonio Dibello; Antonio Daniele; Massimo Petruzzi; Filippo Santarcangelo; Vincenzo Solfrizzi; Daniele Manfredini; Francesco Panza Journal: Geroscience Date: 2022-10-15 Impact factor: 7.581
Authors: Kristen L Nowak; Linda Fried; Anna Jovanovich; Joachim Ix; Kristine Yaffe; Zhiying You; Michel Chonchol Journal: Am J Nephrol Date: 2018-01-24 Impact factor: 3.754
Authors: Yi-Fang Chuang; John C S Breitner; Yen-Ling Chiu; Ara Khachaturian; Kathleen Hayden; Chris Corcoran; JoAnn Tschanz; Maria Norton; Ron Munger; Kathleen Welsh-Bohmer; Peter P Zandi Journal: Neurobiol Aging Date: 2014-05-09 Impact factor: 4.673
Authors: Anne Ws Rutjes; David A Denton; Marcello Di Nisio; Lee-Yee Chong; Rajesh P Abraham; Aalya S Al-Assaf; John L Anderson; Muzaffar A Malik; Robin Wm Vernooij; Gabriel Martínez; Naji Tabet; Jenny McCleery Journal: Cochrane Database Syst Rev Date: 2018-12-17
Authors: Jenny McCleery; Rajesh P Abraham; David A Denton; Anne Ws Rutjes; Lee-Yee Chong; Aalya S Al-Assaf; Daniel J Griffith; Shireen Rafeeq; Hakan Yaman; Muzaffar A Malik; Marcello Di Nisio; Gabriel Martínez; Robin Wm Vernooij; Naji Tabet Journal: Cochrane Database Syst Rev Date: 2018-11-01