Literature DB >> 22860286

Research from the bedside to the lab bench & back.

Robert A White1, Michael Silvey, Derek P Logsdon.   

Abstract

Transgenic mice represent a unique opportunity in biomedical research to discover the genes underlying disease and understand how manipulating the function of single genes and proteins alters physiology in a whole animal system. These advances in biomedical research may accelerate the time between when basic discoveries are made and when the research can be 'translated', that is, when the research will positively impact the lives of patients. The purpose of this article is to present some examples of promising mouse models of human diseases.

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Year:  2012        PMID： 22860286      PMCID： PMC6179705     

Source DB:  PubMed          Journal:  Mo Med        ISSN： 0026-6620


  14 in total

Review 1.  Update on the clinical spectrum and genetics of red blood cell membrane disorders.

Authors:  Patrick G Gallagher
Journal:  Curr Hematol Rep       Date:  2004-03

2.  Positional cloning of the Ttc7 gene required for normal iron homeostasis and mutated in hea and fsn anemia mice.

Authors:  Robert A White; Steven G McNulty; Ndona N Nsumu; Leigh A Boydston; Brandon P Brewer; Koji Shimizu
Journal:  Genomics       Date:  2005-03       Impact factor: 5.736

3.  Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

Authors:  Y Fujiwara; C P Browne; K Cunniff; S C Goff; S H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 4.  Update on iron chelators in thalassemia.

Authors:  Ellis J Neufeld
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2010

Review 5.  Iron-chelating therapy for transfusional iron overload.

Authors:  Gary M Brittenham
Journal:  N Engl J Med       Date:  2011-01-13       Impact factor: 91.245

Review 6.  Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer.

Authors:  Stefan Eber; Samuel E Lux
Journal:  Semin Hematol       Date:  2004-04       Impact factor: 3.851

Review 7.  Disorders of red cell membrane.

Authors:  Xiuli An; Narla Mohandas
Journal:  Br J Haematol       Date:  2008-03-12       Impact factor: 6.998

8.  Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan).

Authors:  Robert A White; Inna V Sokolovsky; Margaret I Britt; Ndona N Nsumu; Derek P Logsdon; Steven G McNulty; Leigh A Wilmes; Brandon P Brewer; Eric Wirtz; Heather R Joyce; Barbara Fegley; Ann Smith; Daniel P Heruth
Journal:  Blood Cells Mol Dis       Date:  2009-05-01       Impact factor: 3.039

9.  Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.

Authors:  Roger Gaedigk; Douglas J Law; Kathleen M Fitzgerald-Gustafson; Steven G McNulty; Ndona N Nsumu; Ann C Modrcin; Robert J Rinaldi; David Pinson; Stephen C Fowler; Mehmet Bilgen; Joanne Burns; Stephen D Hauschka; Robert A White
Journal:  Neuromuscul Disord       Date:  2006-02-17       Impact factor: 4.296

10.  Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse.

Authors:  Robert A White; Steven G McNulty; Shelly Roman; Uttam Garg; Eric Wirtz; Deanna Kohlbrecher; Ndona N Nsumu; David Pinson; Roger Gaedigk; Krista Blackmore; Angela Copple; Sidrah Rasul; Masayo Watanabe; Koji Shimizu
Journal:  Blood       Date:  2004-05-20       Impact factor: 22.113
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