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Literature DB >> 22860165

Special issue on the pharmacology and medicinal chemistry of allosteric modulators of metabotropic glutamate receptors (mGluRs).

Craig W Lindsley.

Abstract

Mesh：

Substances：

Year: 2011 PMID： 22860165 PMCID： PMC3369757 DOI： 10.1021/cn200069d

Source DB: PubMed Journal: ACS Chem Neurosci ISSN： 1948-7193 Impact factor: 4.418

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7 in total

1. Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

Authors: Jose María Cid; Guillaume Duvey; Philippe Cluzeau; Vanthea Nhem; Karim Macary; Alexandre Raux; Nicolas Poirier; Jessica Muller; Christelle Boléa; Terry Finn; Sonia Poli; Mark Epping-Jordan; Emilie Chamelot; Francis Derouet; Francoise Girard; Gregor J Macdonald; Juan Antonio Vega; Ana Isabel de Lucas; Encarnación Matesanz; Hilde Lavreysen; María Lourdes Linares; Daniel Oehlrich; Julen Oyarzábal; Gary Tresadern; Andrés A Trabanco; Jose Ignacio Andrés; Emmanuel Le Poul; Hassan Imogai; Robert Lutjens; Jean-Philippe Rocher
Journal: ACS Chem Neurosci Date: 2010-08-23 Impact factor: 4.418

2. Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

Authors: Richard Williams; Ya Zhou; Colleen M Niswender; Qingwei Luo; P Jeffrey Conn; Craig W Lindsley; Corey R Hopkins
Journal: ACS Chem Neurosci Date: 2010-06-16 Impact factor: 4.418

Review 3. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.

Authors: P Jeffrey Conn; Craig W Lindsley; Carrie K Jones
Journal: Trends Pharmacol Sci Date: 2008-12-06 Impact factor: 14.819

4. Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.

Authors: Ralf Mueller; Alice L Rodriguez; Eric S Dawson; Mariusz Butkiewicz; Thuy T Nguyen; Stephen Oleszkiewicz; Annalen Bleckmann; C David Weaver; Craig W Lindsley; P Jeffrey Conn; Jens Meiler
Journal: ACS Chem Neurosci Date: 2010-01-28 Impact factor: 4.418

Special issue on the pharmacology and medicinal chemistry of allosteric modulators of metabotropic glutamate receptors (mGluRs).

1. Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.

2. Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

Review 3. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.

4. Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.

5. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.

Review 6. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.

Review 7. Metabotropic glutamate receptors: from the workbench to the bedside.