BACKGROUND: Peritoneal dialysis (PD) is the preferred and convenient treatment modality for acute kidney injury (AKI) in children and hemodynamically unstable patients. METHODS: The outcome of acute PD was studied in 57 children (39 boys) with AKI, aged 1 month to 12 years, at a tertiary care center of a teaching hospital in India. RESULTS: Hemolytic uremic syndrome (36.8%) was the most common cause of AKI, followed by septicemia (24.6%) and acute tubular necrosis (19.3%). Treatment with PD was highly effective in lowering retention markers (p < 0.001). Overall mortality was 36.8%. The risk of mortality by multi-variate analysis was higher when patients were anuric [odds ratio (OR): 8.2; 95% confidence interval (CI): 1.3 to 49; p < 0.05], had septicemia (OR: 3.79; 95% CI: 1.55 to 25.8; p < 0.05), or severe infectious complications (OR: 8.2; 95% CI: 1.5 to 42.9; p < 001). CONCLUSIONS: Because of its simplicity and feasibility, acute PD is still an appropriate treatment choice for children with AKI in resource-poor settings. Septicemia and severity of AKI are contributory factors to high mortality in pediatric acute kidney injury.
BACKGROUND: Peritoneal dialysis (PD) is the preferred and convenient treatment modality for acute kidney injury (AKI) in children and hemodynamically unstable patients. METHODS: The outcome of acute PD was studied in 57 children (39 boys) with AKI, aged 1 month to 12 years, at a tertiary care center of a teaching hospital in India. RESULTS:Hemolytic uremic syndrome (36.8%) was the most common cause of AKI, followed by septicemia (24.6%) and acute tubular necrosis (19.3%). Treatment with PD was highly effective in lowering retention markers (p < 0.001). Overall mortality was 36.8%. The risk of mortality by multi-variate analysis was higher when patients were anuric [odds ratio (OR): 8.2; 95% confidence interval (CI): 1.3 to 49; p < 0.05], had septicemia (OR: 3.79; 95% CI: 1.55 to 25.8; p < 0.05), or severe infectious complications (OR: 8.2; 95% CI: 1.5 to 42.9; p < 001). CONCLUSIONS: Because of its simplicity and feasibility, acute PD is still an appropriate treatment choice for children with AKI in resource-poor settings. Septicemia and severity of AKI are contributory factors to high mortality in pediatric acute kidney injury.
Authors: Stuart L Goldstein; Michael J G Somers; Michelle A Baum; Jordan M Symons; Patrick D Brophy; Douglas Blowey; Timothy E Bunchman; Cheryl Baker; Theresa Mottes; Nancy McAfee; Joni Barnett; Gloria Morrison; Kristine Rogers; James D Fortenberry Journal: Kidney Int Date: 2005-02 Impact factor: 10.612
Authors: Paula A Coccia; Flavia B Ramírez; Angela D C Suárez; Laura F Alconcher; Alejandro Balestracci; Laura A García Chervo; Iliana Principi; Aída Vázquez; Viviana M Ratto; María Celia Planells; Jorge Montero; Mariana Saurit; Maria Graciela Pérez Y Gutiérrez; María Celeste Puga; Elsa M Isern; María Carolina Bettendorff; Marcela V Boscardin; Marta Bazán; Mario A Polischuk; Alejo De Sarrasqueta; Adriana Aralde; Diego B Ripeau; Daniela C Leroy; Nahir E Quijada; Romina S Escalante; Marta I Giordano; Cristian Sánchez; Verónica S Selva; Alejandra Caminiti; José María Ojeda; Pablo Bonany; Sandra E Morales; Daniel Allende; María Andrea Arias; Andrea M Exeni; Jésica D Geuna; Larisa Arrúa Journal: Pediatr Nephrol Date: 2021-01-04 Impact factor: 3.714