BACKGROUND AND OBJECTIVES: Clinically, hepatitis B virus (HBV) infection is observed to be associated with nephropathy. However, previous population-based studies failed to show an association between HBV infection and CKD. Therefore, this cross-sectional study was designed to further explore this association. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A representative sample of 6854 Chinese adults aged 30-75 years was tested for levels of serum hepatitis B surface antigen, alanine aminotransferase (ALT), creatinine, urinary albumin/creatinine ratio, and potential CKD risk factors. RESULTS: Neither HBV infection nor elevated ALT (ALT+; ≥ sex-specific 90th percentile of ALT levels of noninfected persons) was significantly associated with reduced estimated GFR (eGFR < 60 ml/min per 1.73 m(2)). Compared with noninfected persons, HBV-infected persons with ALT+, but not those with ALT- (P=0.26), were more likely to have reduced eGFR (odds ratio, 4.07; 95% confidence interval, 1.18-14.0; P=0.03). Further analysis with a general linear model revealed a significant difference in eGFR (mean ± SEM) between HBV-infected and noninfected persons (87.8±0.8 versus 90.2±0.4 ml/min per 1.73 m(2); P=0.002). This difference was mainly derived from that between HBV-infected persons with ALT+ and noninfected persons, with an average difference in eGFR of -4.5 (95% confidence interval, -0.9 to -8.1; P=0.01). HBV infection and ALT+, alone or in combination, were not significantly associated with albuminuria or CKD. CONCLUSIONS: HBV infection with elevated ALT, rather than HBV infection alone, was associated with reduced renal function.
BACKGROUND AND OBJECTIVES: Clinically, hepatitis B virus (HBV) infection is observed to be associated with nephropathy. However, previous population-based studies failed to show an association between HBV infection and CKD. Therefore, this cross-sectional study was designed to further explore this association. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A representative sample of 6854 Chinese adults aged 30-75 years was tested for levels of serum hepatitis B surface antigen, alanine aminotransferase (ALT), creatinine, urinary albumin/creatinine ratio, and potential CKD risk factors. RESULTS: Neither HBV infection nor elevated ALT (ALT+; ≥ sex-specific 90th percentile of ALT levels of noninfected persons) was significantly associated with reduced estimated GFR (eGFR < 60 ml/min per 1.73 m(2)). Compared with noninfected persons, HBV-infectedpersons with ALT+, but not those with ALT- (P=0.26), were more likely to have reduced eGFR (odds ratio, 4.07; 95% confidence interval, 1.18-14.0; P=0.03). Further analysis with a general linear model revealed a significant difference in eGFR (mean ± SEM) between HBV-infected and noninfected persons (87.8±0.8 versus 90.2±0.4 ml/min per 1.73 m(2); P=0.002). This difference was mainly derived from that between HBV-infectedpersons with ALT+ and noninfected persons, with an average difference in eGFR of -4.5 (95% confidence interval, -0.9 to -8.1; P=0.01). HBV infection and ALT+, alone or in combination, were not significantly associated with albuminuria or CKD. CONCLUSIONS:HBV infection with elevated ALT, rather than HBV infection alone, was associated with reduced renal function.
Authors: A Y S Cheng; A P S Kong; V W S Wong; W Y So; H L Y Chan; C S Ho; C W K Lam; J S Tam; C C Chow; C S Cockram; J C N Chan; P C Y Tong Journal: Diabetologia Date: 2006-05-31 Impact factor: 10.122
Authors: Barbora Vozarova; Norbert Stefan; Robert S Lindsay; Aramesh Saremi; Richard E Pratley; Clifton Bogardus; P Antonio Tataranni Journal: Diabetes Date: 2002-06 Impact factor: 9.461
Authors: Sung-Eun Kim; Eun Sun Jang; Moran Ki; Geum-Youn Gwak; Kyung-Ah Kim; Gi-Ae Kim; Do Young Kim; Dong Joon Kim; Man Woo Kim; Yun Soo Kim; Young Seok Kim; In Hee Kim; Chang Wook Kim; Ho Dong Kim; Hyung Joon Kim; Neung Hwa Park; Soon Koo Baik; Jeong Ill Suh; Byung-Cheol Song; Il Han Song; Jong Eun Yeon; Byung Seok Lee; Youn Jae Lee; Young Kul Jung; Woo Jin Chung; Sung Bum Cho; Eun-Young Cho; Hyun Chin Cho; Gab Jin Cheon; Hee Bok Chae; DaeHee Choi; Sung-Kyu Choi; Hwa Young Choi; Won Young Tak; Jeong Heo; Sook-Hyang Jeong Journal: J Korean Med Sci Date: 2018-09-12 Impact factor: 2.153