OBJECTIVE: Mutations in the KCNJ11 and ABCC8 genes that encode the pancreatic K(ATP) channel are the commonest cause of permanent neonatal diabetes mellitus (PNDM). The authors aimed to define the genetic causes of PNDM in a large cohort of Arab patients and compare them with a British cohort tested in the same laboratory. DESIGN: Retrospective observational study. SETTING: International genetics centre. PATIENTS: Arab and British subjects with PNDM who were referred for genetic testing over the same period. INTERVENTION: Comparison of genotypes and phenotypes between the two cohorts. MAIN OUTCOME MEASURES: The aetiology and phenotype of PNDM in an Arab compared to a British cohort. RESULTS: 88 Arab and 77 British probands were referred between 2006 and 2011, inclusive. Consanguinity was higher among Arabs (63.6% vs 10.4%) and a higher percentage had a genetic diagnosis compared to the British cohort (63.6% vs 41.6%). Recessive EIF2AK3 gene mutations were the commonest cause of PNDM in the Arab cohort (22.7%) followed by INS (12.5%), and KCNJ11 and GCK (5.7% each), whereas K(ATP) channel mutations were the commonest cause (29.9%) in the British cohort. In 37.5% of Arab patients PNDM was part of a genetic syndrome compared to 7.8% of the British cohort. CONCLUSION: PNDM in the Arab population has a different genetic spectrum compared to British patients where KATP channel mutations are the commonest cause, similar to other European populations. In Arabs, PNDM is more likely to be part of a recessively inherited syndrome, possibly due to the higher rate of consanguinity.
OBJECTIVE: Mutations in the KCNJ11 and ABCC8 genes that encode the pancreatic K(ATP) channel are the commonest cause of permanent neonatal diabetes mellitus (PNDM). The authors aimed to define the genetic causes of PNDM in a large cohort of Arab patients and compare them with a British cohort tested in the same laboratory. DESIGN: Retrospective observational study. SETTING: International genetics centre. PATIENTS: Arab and British subjects with PNDM who were referred for genetic testing over the same period. INTERVENTION: Comparison of genotypes and phenotypes between the two cohorts. MAIN OUTCOME MEASURES: The aetiology and phenotype of PNDM in an Arab compared to a British cohort. RESULTS: 88 Arab and 77 British probands were referred between 2006 and 2011, inclusive. Consanguinity was higher among Arabs (63.6% vs 10.4%) and a higher percentage had a genetic diagnosis compared to the British cohort (63.6% vs 41.6%). Recessive EIF2AK3 gene mutations were the commonest cause of PNDM in the Arab cohort (22.7%) followed by INS (12.5%), and KCNJ11 and GCK (5.7% each), whereas K(ATP) channel mutations were the commonest cause (29.9%) in the British cohort. In 37.5% of Arab patients PNDM was part of a genetic syndrome compared to 7.8% of the British cohort. CONCLUSION: PNDM in the Arab population has a different genetic spectrum compared to British patients where KATP channel mutations are the commonest cause, similar to other European populations. In Arabs, PNDM is more likely to be part of a recessively inherited syndrome, possibly due to the higher rate of consanguinity.
Authors: H U Irgens; J Molnes; B B Johansson; M Ringdal; T Skrivarhaug; D E Undlien; O Søvik; G Joner; A Molven; P R Njølstad Journal: Diabetologia Date: 2013-04-27 Impact factor: 10.122
Authors: Abdelhadi M Habeb; Asma Deeb; Matthew Johnson; Mohammed Abdullah; Majidah Abdulrasoul; Hussain Al-Awneh; Mohammed S F Al-Maghamsi; Fathiya Al-Murshedi; Ramlah Al-Saif; Siham Al-Sinani; Dina Ramadan; Hala Tfayli; Sarah E Flanagan; Sian Ellard Journal: Horm Res Paediatr Date: 2015-02-05 Impact factor: 2.852
Authors: Huseyin Demirbilek; Ved Bhushan Arya; Mehmet Nuri Ozbek; Jayne A L Houghton; Riza Taner Baran; Melek Akar; Selahattin Tekes; Heybet Tuzun; Deborah J Mackay; Sarah E Flanagan; Andrew T Hattersley; Sian Ellard; Khalid Hussain Journal: Eur J Endocrinol Date: 2015-03-09 Impact factor: 6.664