BACKGROUND: Locally advanced breast cancer (LABC) is still common in developing countries. The association between neoadjuvant chemotherapy (NC) and oncoplastic surgery (OS) might provide an oncological treatment with satisfactory aesthetic results. PURPOSE: The goal was to demonstrate if oncoplastic surgical techniques can be utilized to treat LABC which was submitted to neoadjuvant chemotherapy. METHODS: This prospective clinical trial included breast cancer patients, clinical stage III, who underwent established NC regimen. All patients underwent preoperative planning to control the tumor size and to define the surgical technique. A detailed analysis of the pathological specimen was performed. RESULTS: 50 patients were assessed and surgically treated. Tumor size ranged from 3.0 to 14.0 cm (median 6.5 cm). Pathologic response was rated as stable, progressive, partial response, and complete response in 10%, 8%, 80% and 2% of the cases, respectively. Seventeen (34%) patients were submitted to OS. No patient had positive margins. Skin involvement was presented in 36% of pathologic specimen. CONCLUSIONS: Oncoplastic surgical techniques for selected patients decrease the rates of radical surgery despite large tumors. (www.clinicaltrials.gov, NCT00820690).
BACKGROUND: Locally advanced breast cancer (LABC) is still common in developing countries. The association between neoadjuvant chemotherapy (NC) and oncoplastic surgery (OS) might provide an oncological treatment with satisfactory aesthetic results. PURPOSE: The goal was to demonstrate if oncoplastic surgical techniques can be utilized to treat LABC which was submitted to neoadjuvant chemotherapy. METHODS: This prospective clinical trial included breast cancerpatients, clinical stage III, who underwent established NC regimen. All patients underwent preoperative planning to control the tumor size and to define the surgical technique. A detailed analysis of the pathological specimen was performed. RESULTS: 50 patients were assessed and surgically treated. Tumor size ranged from 3.0 to 14.0 cm (median 6.5 cm). Pathologic response was rated as stable, progressive, partial response, and complete response in 10%, 8%, 80% and 2% of the cases, respectively. Seventeen (34%) patients were submitted to OS. No patient had positive margins. Skin involvement was presented in 36% of pathologic specimen. CONCLUSIONS: Oncoplastic surgical techniques for selected patients decrease the rates of radical surgery despite large tumors. (www.clinicaltrials.gov, NCT00820690).
Authors: Gustavo Zucca-Matthes; Andrea Manconi; Rene Aloísio da Costa Viera; Rodrigo Augusto Depieri Michelli; Angelo do Carmo Silva Matthes Journal: Gland Surg Date: 2013-05
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Authors: Guilherme Freire Angotti Carrara; Cristovam Scapulatempo-Neto; Lucas Faria Abrahão-Machado; Maria Mitzi Brentani; João Soares Nunes; Maria Aparecida Azevedo Koike Folgueira; René Aloisio da Costa Vieira Journal: Clinics (Sao Paulo) Date: 2017-03 Impact factor: 2.365
Authors: René Aloisio da Costa Vieira; Guilherme Freire Angotti Carrara; Cristovam Scapulatempo Neto; Mariana Andozia Morini; Maria Mitzi Brentani; Maria Aparecida Azevedo Koike Folgueira Journal: Ann Med Surg (Lond) Date: 2016-08-03