Literature DB >> 22858252

Homeostatic mechanisms by alternative forms of tRNA synthetases.

Min Guo1, Paul Schimmel.   

Abstract

Although aminoacyl tRNA synthetases (aaRSs) act in translation, numerous examples demonstrate ex-translational functions in fundamental networks of higher organisms. These functions involve modified versions of aaRSs and natural fragments. The interplay of aaRS-derived entities appears to be at the heart of homeostatic mechanisms controlling angiogenesis, inflammation, metabolism, and tumorigenesis.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22858252      PMCID： PMC3459177          DOI： 10.1016/j.tibs.2012.07.003

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  10 in total

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Authors:  Jin Woo Choi; Jeong-Won Lee; Jun Ki Kim; Hye-Kyung Jeon; Jung-Joo Choi; Dae Gyu Kim; Byoung-Gie Kim; Do-Hyun Nam; Hong Joong Kim; Seok Hyun Yun; Sunghoon Kim
Journal:  J Mol Cell Biol       Date:  2012-04-24       Impact factor: 6.216

3.  Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.

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Journal:  Cell       Date:  2012-03-01       Impact factor: 41.582

4.  tRNA-controlled nuclear import of a human tRNA synthetase.

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Journal:  J Biol Chem       Date:  2012-01-30       Impact factor: 5.157

5.  AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.

Authors:  Jung Min Han; Bum-Joon Park; Sang Gyu Park; Young Sun Oh; So Jung Choi; Sang Won Lee; Soon-Kyung Hwang; Seung-Hee Chang; Myung-Haing Cho; Sunghoon Kim
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Review 6.  The GAIT system: a gatekeeper of inflammatory gene expression.

Authors:  Rupak Mukhopadhyay; Jie Jia; Abul Arif; Partho Sarothi Ray; Paul L Fox
Journal:  Trends Biochem Sci       Date:  2009-06-15       Impact factor: 13.807

7.  Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.

Authors:  Min Jung Kim; Bum-Joon Park; Young-Sun Kang; Hyoung June Kim; Jae-Hyun Park; Jung Woo Kang; Sang Won Lee; Jung Min Han; Han-Woong Lee; Sunghoon Kim
Journal:  Nat Genet       Date:  2003-07       Impact factor: 38.330

8.  p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.

Authors:  Jin Young Kim; Young-Sun Kang; Joong-Won Lee; Hyoung June Kim; Young Ha Ahn; Heonyong Park; Young-Gyu Ko; Sunghoon Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

9.  Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.

Authors:  Jin Woo Choi; Dae Gyu Kim; Al-Eum Lee; Hye Rim Kim; Jin Young Lee; Nam Hoon Kwon; Young Kee Shin; Soon-Kyung Hwang; Seung-Hee Chang; Myung-Haing Cho; Yoon-La Choi; Jhingook Kim; Seung Hyun Oh; Bora Kim; Soo-Youl Kim; Hyo-Sung Jeon; Jae Yong Park; Hyunseok Peter Kang; Bum Joon Park; Jung Min Han; Sunghoon Kim
Journal:  PLoS Genet       Date:  2011-03-31       Impact factor: 5.917

10.  A stress-responsive RNA switch regulates VEGFA expression.

Authors:  Partho Sarothi Ray; Jie Jia; Peng Yao; Mithu Majumder; Maria Hatzoglou; Paul L Fox
Journal:  Nature       Date:  2008-12-21       Impact factor: 49.962
  10 in total
  4 in total

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Authors:  Sandeepa M Eswarappa; Paul L Fox
Journal:  Trends Biochem Sci       Date:  2013-02-14       Impact factor: 13.807

2.  Studying nuclear functions of aminoacyl tRNA synthetases.

Authors:  Yi Shi; Na Wei; Xiang-Lei Yang
Journal:  Methods       Date:  2016-09-21       Impact factor: 3.608

3.  Taking AIM at the start of translation.

Authors:  Medha Raina; Michael Ibba
Journal:  J Mol Biol       Date:  2012-08-25       Impact factor: 5.469

4.  Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.

Authors:  Daniel Castranova; Andrew E Davis; Brigid D Lo; Mayumi F Miller; Paul J Paukstelis; Matthew R Swift; Van N Pham; Jesús Torres-Vázquez; Kameha Bell; Kenna M Shaw; Makoto Kamei; Brant M Weinstein
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-01-28       Impact factor: 8.311
  4 in total

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