| Literature DB >> 22858144 |
Ravindra M Kumbhare1, Umesh B Kosurkar, M Janaki Ramaiah, Tulshiram L Dadmal, S N C V L Pushpavalli, Manika Pal-Bhadra.
Abstract
A new series of isoxazoles and triazoles linked 2-phenyl benzothiazole were synthesized and evaluated for their anticancer activity. These compounds have been tested for their cytotoxicity three cancer cell lines. Among the compounds tested, compound 5d showed good cytotoxicity against Colo-205 and A549 cells in comparison to standard control PMX 610(1). Further compound 5d has been tested for its apoptotic activity and its inhibitory activity against caspase and PARP proteins. Hence this compound has the potential that it can be selected for further biological studies.Entities:
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Year: 2012 PMID： 22858144 DOI： 10.1016/j.bmcl.2012.07.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823