| Literature DB >> 22858098 |
Werner J Geldenhuys1, Phani K Talasila, Prabodh Sadana.
Abstract
The serum and glucocorticoid regulated kinase-1 (SGK1) is part of the serine/threonine kinase family and has therapeutic potential in several neurodegenerative diseases such as ischemic stroke and Parkinson's disease. Here we use structure-based virtual screening to identify a novel ligand which inhibits SGK1 activity. The data presented here can be used for future scaffold hopping and possible drug development efforts.Entities:
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Year: 2012 PMID： 22858098 DOI： 10.1016/j.bmcl.2012.06.096
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823