PURPOSE: Familial amyloidosis with polyneuropathy (FAP) sometimes courses with vitreous amyloid. The aim of this study was to evaluate the incidence of glaucoma after vitrectomy in FAP patients. METHODS: A total of 79 eyes of 42 liver transplanted FAP patients and 16 eyes of 16 non-FAP patients with rhegmatogenous retina detachment were collected. The patients were divided in to three groups: Group I - FAP patients with vitreous opacities submitted to vitrectomy, Group II - FAP patients without vitreous opacities and not submitted to vitrectomy and, Group III - non-FAP patients with rhegmatogenous retinal detachment submitted to vitrectomy. The Group I was subdivided into: Ia - "complete" vitrectomy; Ib - "incomplete" vitrectomy. The onset of glaucoma was considered when the intraocular pressure level was higher than 21 mmHg, with concomitant visual field abnormalities and optic nerve cupping. RESULTS: Post vitrectomy glaucoma was more frequent in Group I (56.1%) than in Group III (12.5%) and in Group II (10.5%). We observed a higher incidence of glaucoma in the Ia than in the Ib subgroup (86.4 vs. 21.1%) and earlier appearance in subgroup Ia (7.9 ± 3.6 vs. 39.5 ± 6.6 months). CONCLUSION: Vitrectomy induced the development of glaucoma in FAP patients.
PURPOSE:Familial amyloidosis with polyneuropathy (FAP) sometimes courses with vitreous amyloid. The aim of this study was to evaluate the incidence of glaucoma after vitrectomy in FAPpatients. METHODS: A total of 79 eyes of 42 liver transplanted FAPpatients and 16 eyes of 16 non-FAPpatients with rhegmatogenous retina detachment were collected. The patients were divided in to three groups: Group I - FAPpatients with vitreous opacities submitted to vitrectomy, Group II - FAPpatients without vitreous opacities and not submitted to vitrectomy and, Group III - non-FAPpatients with rhegmatogenous retinal detachment submitted to vitrectomy. The Group I was subdivided into: Ia - "complete" vitrectomy; Ib - "incomplete" vitrectomy. The onset of glaucoma was considered when the intraocular pressure level was higher than 21 mmHg, with concomitant visual field abnormalities and optic nerve cupping. RESULTS: Post vitrectomy glaucoma was more frequent in Group I (56.1%) than in Group III (12.5%) and in Group II (10.5%). We observed a higher incidence of glaucoma in the Ia than in the Ib subgroup (86.4 vs. 21.1%) and earlier appearance in subgroup Ia (7.9 ± 3.6 vs. 39.5 ± 6.6 months). CONCLUSION: Vitrectomy induced the development of glaucoma in FAPpatients.
Authors: Ana Marta; Rita Vieira; Ana Figueiredo; Rita Reis; Isabel Sampaio; João Melo Beirão; Maria João Menéres Journal: Eye (Lond) Date: 2021-02-24 Impact factor: 3.775
Authors: Roxanna Perez-Garmendia; Alicia Lopez de Eguileta Rodriguez; Ivan Ramos-Martinez; Nayeli Martínez Zuñiga; Roberto Gonzalez-Salinas; Hugo Quiroz-Mercado; Edgar Zenteno; Eleazar Ramírez Hernández; Luis Fernando Hernández-Zimbrón Journal: Oxid Med Cell Longev Date: 2020-06-03 Impact factor: 6.543