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Literature DB >> 22856375

EnigmaVis: online interactive visualization of genome-wide association studies of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium.

Nic M Novak¹, Jason L Stein, Sarah E Medland, Derrek P Hibar, Paul M Thompson, Arthur W Toga.

Abstract

In an attempt to increase power to detect genetic associations with brain phenotypes derived from human neuroimaging data, we recently conducted a large-scale, genome-wide association meta-analysis of hippocampal, brain, and intracranial volume through the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. Here, we present a freely available online interactive tool, EnigmaVis, which makes it easy to visualize the association results generated by the consortium alongside allele frequency, genes, and functional annotations. EnigmaVis runs natively within the web browser, and generates plots that show the level of association between brain phenotypes at user-specified genomic positions. Uniquely, EnigmaVis is dynamic; users can interact with elements on the plot in real time. This software will be useful when exploring the effect on brain structure of particular genetic variants influencing neuropsychiatric illness and cognitive function. Future projects of the consortium and updates to EnigmaVis will also be displayed on the site. EnigmaVis is freely available online at http://enigma.loni.ucla.edu/enigma-vis/

Entities: Disease Species

Mesh：

Year: 2012 PMID： 22856375 PMCID： PMC3635713 DOI： 10.1017/thg.2012.17

Source DB: PubMed Journal: Twin Res Hum Genet ISSN： 1832-4274 Impact factor: 1.587

12 in total

1. Genetic influences on brain structure.

Authors: P M Thompson; T D Cannon; K L Narr; T van Erp; V P Poutanen; M Huttunen; J Lönnqvist; C G Standertskjöld-Nordenstam; J Kaprio; M Khaledy; R Dail; C I Zoumalan; A W Toga
Journal: Nat Neurosci Date: 2001-12 Impact factor: 24.884

2. The human genome browser at UCSC.

Authors: W James Kent; Charles W Sugnet; Terrence S Furey; Krishna M Roskin; Tom H Pringle; Alan M Zahler; David Haussler
Journal: Genome Res Date: 2002-06 Impact factor: 9.043

3. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.

Authors: Lars Bertram; Matthew B McQueen; Kristina Mullin; Deborah Blacker; Rudolph E Tanzi
Journal: Nat Genet Date: 2007-01 Impact factor: 38.330

Review 4. Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

Authors: Mark I McCarthy; Gonçalo R Abecasis; Lon R Cardon; David B Goldstein; Julian Little; John P A Ioannidis; Joel N Hirschhorn
Journal: Nat Rev Genet Date: 2008-05 Impact factor: 53.242

5. Integrating common and rare genetic variation in diverse human populations.

Authors: David M Altshuler; Richard A Gibbs; Leena Peltonen; David M Altshuler; Richard A Gibbs; Leena Peltonen; Emmanouil Dermitzakis; Stephen F Schaffner; Fuli Yu; Leena Peltonen; Emmanouil Dermitzakis; Penelope E Bonnen; David M Altshuler; Richard A Gibbs; Paul I W de Bakker; Panos Deloukas; Stacey B Gabriel; Rhian Gwilliam; Sarah Hunt; Michael Inouye; Xiaoming Jia; Aarno Palotie; Melissa Parkin; Pamela Whittaker; Fuli Yu; Kyle Chang; Alicia Hawes; Lora R Lewis; Yanru Ren; David Wheeler; Richard A Gibbs; Donna Marie Muzny; Chris Barnes; Katayoon Darvishi; Matthew Hurles; Joshua M Korn; Kati Kristiansson; Charles Lee; Steven A McCarrol; James Nemesh; Emmanouil Dermitzakis; Alon Keinan; Stephen B Montgomery; Samuela Pollack; Alkes L Price; Nicole Soranzo; Penelope E Bonnen; Richard A Gibbs; Claudia Gonzaga-Jauregui; Alon Keinan; Alkes L Price; Fuli Yu; Verneri Anttila; Wendy Brodeur; Mark J Daly; Stephen Leslie; Gil McVean; Loukas Moutsianas; Huy Nguyen; Stephen F Schaffner; Qingrun Zhang; Mohammed J R Ghori; Ralph McGinnis; William McLaren; Samuela Pollack; Alkes L Price; Stephen F Schaffner; Fumihiko Takeuchi; Sharon R Grossman; Ilya Shlyakhter; Elizabeth B Hostetter; Pardis C Sabeti; Clement A Adebamowo; Morris W Foster; Deborah R Gordon; Julio Licinio; Maria Cristina Manca; Patricia A Marshall; Ichiro Matsuda; Duncan Ngare; Vivian Ota Wang; Deepa Reddy; Charles N Rotimi; Charmaine D Royal; Richard R Sharp; Changqing Zeng; Lisa D Brooks; Jean E McEwen
Journal: Nature Date: 2010-09-02 Impact factor: 49.962

6. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.

Authors: Benjamin M Neale; Sarah E Medland; Stephan Ripke; Philip Asherson; Barbara Franke; Klaus-Peter Lesch; Stephen V Faraone; Thuy Trang Nguyen; Helmut Schäfer; Peter Holmans; Mark Daly; Hans-Christoph Steinhausen; Christine Freitag; Andreas Reif; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Susanne Walitza; Andreas Warnke; Jobst Meyer; Haukur Palmason; Jan Buitelaar; Alejandro Arias Vasquez; Nanda Lambregts-Rommelse; Michael Gill; Richard J L Anney; Kate Langely; Michael O'Donovan; Nigel Williams; Michael Owen; Anita Thapar; Lindsey Kent; Joseph Sergeant; Herbert Roeyers; Eric Mick; Joseph Biederman; Alysa Doyle; Susan Smalley; Sandra Loo; Hakon Hakonarson; Josephine Elia; Alexandre Todorov; Ana Miranda; Fernando Mulas; Richard P Ebstein; Aribert Rothenberger; Tobias Banaschewski; Robert D Oades; Edmund Sonuga-Barke; James McGough; Laura Nisenbaum; Frank Middleton; Xiaolan Hu; Stan Nelson
Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-08-01 Impact factor: 8.829

7. Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study.

Authors: William S Kremen; Elizabeth Prom-Wormley; Matthew S Panizzon; Lisa T Eyler; Bruce Fischl; Michael C Neale; Carol E Franz; Michael J Lyons; Jennifer Pacheco; Michele E Perry; Allison Stevens; J Eric Schmitt; Michael D Grant; Larry J Seidman; Heidi W Thermenos; Ming T Tsuang; Seth A Eisen; Anders M Dale; Christine Fennema-Notestine
Journal: Neuroimage Date: 2009-09-26 Impact factor: 6.556

Review 8. Genomewide association studies: history, rationale, and prospects for psychiatric disorders.

Authors: Sven Cichon; Nick Craddock; Mark Daly; Stephen V Faraone; Pablo V Gejman; John Kelsoe; Thomas Lehner; Douglas F Levinson; Audra Moran; Pamela Sklar; Patrick F Sullivan
Journal: Am J Psychiatry Date: 2009-04-01 Impact factor: 18.112

Review 9. Genetic influences on human brain structure: a review of brain imaging studies in twins.

Authors: Jiska S Peper; Rachel M Brouwer; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol
Journal: Hum Brain Mapp Date: 2007-06 Impact factor: 5.038

10. Identification of common variants associated with human hippocampal and intracranial volumes.

Authors: Jason L Stein; Sarah E Medland; Alejandro Arias Vasquez; Derrek P Hibar; Rudy E Senstad; Anderson M Winkler; Roberto Toro; Katja Appel; Richard Bartecek; Ørjan Bergmann; Manon Bernard; Andrew A Brown; Dara M Cannon; M Mallar Chakravarty; Andrea Christoforou; Martin Domin; Oliver Grimm; Marisa Hollinshead; Avram J Holmes; Georg Homuth; Jouke-Jan Hottenga; Camilla Langan; Lorna M Lopez; Narelle K Hansell; Kristy S Hwang; Sungeun Kim; Gonzalo Laje; Phil H Lee; Xinmin Liu; Eva Loth; Anbarasu Lourdusamy; Morten Mattingsdal; Sebastian Mohnke; Susana Muñoz Maniega; Kwangsik Nho; Allison C Nugent; Carol O'Brien; Martina Papmeyer; Benno Pütz; Adaikalavan Ramasamy; Jerod Rasmussen; Mark Rijpkema; Shannon L Risacher; J Cooper Roddey; Emma J Rose; Mina Ryten; Li Shen; Emma Sprooten; Eric Strengman; Alexander Teumer; Daniah Trabzuni; Jessica Turner; Kristel van Eijk; Theo G M van Erp; Marie-Jose van Tol; Katharina Wittfeld; Christiane Wolf; Saskia Woudstra; Andre Aleman; Saud Alhusaini; Laura Almasy; Elisabeth B Binder; David G Brohawn; Rita M Cantor; Melanie A Carless; Aiden Corvin; Michael Czisch; Joanne E Curran; Gail Davies; Marcio A A de Almeida; Norman Delanty; Chantal Depondt; Ravi Duggirala; Thomas D Dyer; Susanne Erk; Jesen Fagerness; Peter T Fox; Nelson B Freimer; Michael Gill; Harald H H Göring; Donald J Hagler; David Hoehn; Florian Holsboer; Martine Hoogman; Norbert Hosten; Neda Jahanshad; Matthew P Johnson; Dalia Kasperaviciute; Jack W Kent; Peter Kochunov; Jack L Lancaster; Stephen M Lawrie; David C Liewald; René Mandl; Mar Matarin; Manuel Mattheisen; Eva Meisenzahl; Ingrid Melle; Eric K Moses; Thomas W Mühleisen; Matthias Nauck; Markus M Nöthen; Rene L Olvera; Massimo Pandolfo; G Bruce Pike; Ralf Puls; Ivar Reinvang; Miguel E Rentería; Marcella Rietschel; Joshua L Roffman; Natalie A Royle; Dan Rujescu; Jonathan Savitz; Hugo G Schnack; Knut Schnell; Nina Seiferth; Colin Smith; Vidar M Steen; Maria C Valdés Hernández; Martijn Van den Heuvel; Nic J van der Wee; Neeltje E M Van Haren; Joris A Veltman; Henry Völzke; Robert Walker; Lars T Westlye; Christopher D Whelan; Ingrid Agartz; Dorret I Boomsma; Gianpiero L Cavalleri; Anders M Dale; Srdjan Djurovic; Wayne C Drevets; Peter Hagoort; Jeremy Hall; Andreas Heinz; Clifford R Jack; Tatiana M Foroud; Stephanie Le Hellard; Fabio Macciardi; Grant W Montgomery; Jean Baptiste Poline; David J Porteous; Sanjay M Sisodiya; John M Starr; Jessika Sussmann; Arthur W Toga; Dick J Veltman; Henrik Walter; Michael W Weiner; Joshua C Bis; M Arfan Ikram; Albert V Smith; Vilmundur Gudnason; Christophe Tzourio; Meike W Vernooij; Lenore J Launer; Charles DeCarli; Sudha Seshadri; Ole A Andreassen; Liana G Apostolova; Mark E Bastin; John Blangero; Han G Brunner; Randy L Buckner; Sven Cichon; Giovanni Coppola; Greig I de Zubicaray; Ian J Deary; Gary Donohoe; Eco J C de Geus; Thomas Espeseth; Guillén Fernández; David C Glahn; Hans J Grabe; John Hardy; Hilleke E Hulshoff Pol; Mark Jenkinson; René S Kahn; Colm McDonald; Andrew M McIntosh; Francis J McMahon; Katie L McMahon; Andreas Meyer-Lindenberg; Derek W Morris; Bertram Müller-Myhsok; Thomas E Nichols; Roel A Ophoff; Tomas Paus; Zdenka Pausova; Brenda W Penninx; Steven G Potkin; Philipp G Sämann; Andrew J Saykin; Gunter Schumann; Jordan W Smoller; Joanna M Wardlaw; Michael E Weale; Nicholas G Martin; Barbara Franke; Margaret J Wright; Paul M Thompson
Journal: Nat Genet Date: 2012-04-15 Impact factor: 38.330

21 in total

1. Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts.

Authors: Derrek P Hibar; Jason L Stein; Neda Jahanshad; Omid Kohannim; Arthur W Toga; Katie L McMahon; Greig I de Zubicaray; Grant W Montgomery; Nicholas G Martin; Margaret J Wright; Michael W Weiner; Paul M Thompson
Journal: Med Image Comput Comput Assist Interv Date: 2013

2. Genome-wide interaction analysis reveals replicated epistatic effects on brain structure.

Authors: Derrek P Hibar; Jason L Stein; Neda Jahanshad; Omid Kohannim; Xue Hua; Arthur W Toga; Katie L McMahon; Greig I de Zubicaray; Nicholas G Martin; Margaret J Wright; Michael W Weiner; Paul M Thompson
Journal: Neurobiol Aging Date: 2014-08-27 Impact factor: 4.673

3. Gene-based GWAS and biological pathway analysis of the resilience of executive functioning.

Authors: Shubhabrata Mukherjee; Sungeun Kim; Vijay K Ramanan; Laura E Gibbons; Kwangsik Nho; M Maria Glymour; Nilüfer Ertekin-Taner; Thomas J Montine; Andrew J Saykin; Paul K Crane
Journal: Brain Imaging Behav Date: 2014-03 Impact factor: 3.978

4. Genetic clustering on the hippocampal surface for genome-wide association studies.

Authors: Derrek P Hibar; Sarah E Medland; Jason L Stein; Sungeun Kim; Li Shen; Andrew J Saykin; Greig I de Zubicaray; Katie L McMahon; Grant W Montgomery; Nicholas G Martin; Margaret J Wright; Srdjan Djurovic; Ingrid A Agartz; Ole A Andreassen; Paul M Thompson
Journal: Med Image Comput Comput Assist Interv Date: 2013

Review 5. Genetics of the connectome.

Authors: Paul M Thompson; Tian Ge; David C Glahn; Neda Jahanshad; Thomas E Nichols
Journal: Neuroimage Date: 2013-05-21 Impact factor: 6.556

6. Selected rapporteur summaries from the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 14-18, 2012.

Authors: Heike Anderson-Schmidt; Olga Beltcheva; Mariko D Brandon; Enda M Byrne; Eric J Diehl; Laramie Duncan; Suzanne D Gonzalez; Eilis Hannon; Katri Kantojärvi; Iordanis Karagiannidis; Mark Z Kos; Eszter Kotyuk; Benjamin I Laufer; Katarzyna Mantha; Nathaniel W McGregor; Sandra Meier; Vanessa Nieratschker; Helen Spiers; Alessio Squassina; Geeta A Thakur; Yash Tiwari; Biju Viswanath; Michael J Way; Cybele C P Wong; Anne O'Shea; Lynn E DeLisi
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2013-01-22 Impact factor: 3.568

7. Neuroimaging and genetics: exploring, searching, and finding.

Authors: Dirk J A Smit; Dennis van 't Ent; Greig de Zubicaray; Jason L Stein
Journal: Twin Res Hum Genet Date: 2012-06 Impact factor: 1.587

8. The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools.

Authors: Ivo D Dinov; Petros Petrosyan; Zhizhong Liu; Paul Eggert; Alen Zamanyan; Federica Torri; Fabio Macciardi; Sam Hobel; Seok Woo Moon; Young Hee Sung; Zhiguo Jiang; Jennifer Labus; Florian Kurth; Cody Ashe-McNalley; Emeran Mayer; Paul M Vespa; John D Van Horn; Arthur W Toga
Journal: Brain Imaging Behav Date: 2014-06 Impact factor: 3.978

Review 9. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.

Authors: Paul M Thompson; Jason L Stein; Sarah E Medland; Derrek P Hibar; Alejandro Arias Vasquez; Miguel E Renteria; Roberto Toro; Neda Jahanshad; Gunter Schumann; Barbara Franke; Margaret J Wright; Nicholas G Martin; Ingrid Agartz; Martin Alda; Saud Alhusaini; Laura Almasy; Jorge Almeida; Kathryn Alpert; Nancy C Andreasen; Ole A Andreassen; Liana G Apostolova; Katja Appel; Nicola J Armstrong; Benjamin Aribisala; Mark E Bastin; Michael Bauer; Carrie E Bearden; Orjan Bergmann; Elisabeth B Binder; John Blangero; Henry J Bockholt; Erlend Bøen; Catherine Bois; Dorret I Boomsma; Tom Booth; Ian J Bowman; Janita Bralten; Rachel M Brouwer; Han G Brunner; David G Brohawn; Randy L Buckner; Jan Buitelaar; Kazima Bulayeva; Juan R Bustillo; Vince D Calhoun; Dara M Cannon; Rita M Cantor; Melanie A Carless; Xavier Caseras; Gianpiero L Cavalleri; M Mallar Chakravarty; Kiki D Chang; Christopher R K Ching; Andrea Christoforou; Sven Cichon; Vincent P Clark; Patricia Conrod; Giovanni Coppola; Benedicto Crespo-Facorro; Joanne E Curran; Michael Czisch; Ian J Deary; Eco J C de Geus; Anouk den Braber; Giuseppe Delvecchio; Chantal Depondt; Lieuwe de Haan; Greig I de Zubicaray; Danai Dima; Rali Dimitrova; Srdjan Djurovic; Hongwei Dong; Gary Donohoe; Ravindranath Duggirala; Thomas D Dyer; Stefan Ehrlich; Carl Johan Ekman; Torbjørn Elvsåshagen; Louise Emsell; Susanne Erk; Thomas Espeseth; Jesen Fagerness; Scott Fears; Iryna Fedko; Guillén Fernández; Simon E Fisher; Tatiana Foroud; Peter T Fox; Clyde Francks; Sophia Frangou; Eva Maria Frey; Thomas Frodl; Vincent Frouin; Hugh Garavan; Sudheer Giddaluru; David C Glahn; Beata Godlewska; Rita Z Goldstein; Randy L Gollub; Hans J Grabe; Oliver Grimm; Oliver Gruber; Tulio Guadalupe; Raquel E Gur; Ruben C Gur; Harald H H Göring; Saskia Hagenaars; Tomas Hajek; Geoffrey B Hall; Jeremy Hall; John Hardy; Catharina A Hartman; Johanna Hass; Sean N Hatton; Unn K Haukvik; Katrin Hegenscheid; Andreas Heinz; Ian B Hickie; Beng-Choon Ho; David Hoehn; Pieter J Hoekstra; Marisa Hollinshead; Avram J Holmes; Georg Homuth; Martine Hoogman; L Elliot Hong; Norbert Hosten; Jouke-Jan Hottenga; Hilleke E Hulshoff Pol; Kristy S Hwang; Clifford R Jack; Mark Jenkinson; Caroline Johnston; Erik G Jönsson; René S Kahn; Dalia Kasperaviciute; Sinead Kelly; Sungeun Kim; Peter Kochunov; Laura Koenders; Bernd Krämer; John B J Kwok; Jim Lagopoulos; Gonzalo Laje; Mikael Landen; Bennett A Landman; John Lauriello; Stephen M Lawrie; Phil H Lee; Stephanie Le Hellard; Herve Lemaître; Cassandra D Leonardo; Chiang-Shan Li; Benny Liberg; David C Liewald; Xinmin Liu; Lorna M Lopez; Eva Loth; Anbarasu Lourdusamy; Michelle Luciano; Fabio Macciardi; Marise W J Machielsen; Glenda M Macqueen; Ulrik F Malt; René Mandl; Dara S Manoach; Jean-Luc Martinot; Mar Matarin; Karen A Mather; Manuel Mattheisen; Morten Mattingsdal; Andreas Meyer-Lindenberg; Colm McDonald; Andrew M McIntosh; Francis J McMahon; Katie L McMahon; Eva Meisenzahl; Ingrid Melle; Yuri Milaneschi; Sebastian Mohnke; Grant W Montgomery; Derek W Morris; Eric K Moses; Bryon A Mueller; Susana Muñoz Maniega; Thomas W Mühleisen; Bertram Müller-Myhsok; Benson Mwangi; Matthias Nauck; Kwangsik Nho; Thomas E Nichols; Lars-Göran Nilsson; Allison C Nugent; Lars Nyberg; Rene L Olvera; Jaap Oosterlaan; Roel A Ophoff; Massimo Pandolfo; Melina Papalampropoulou-Tsiridou; Martina Papmeyer; Tomas Paus; Zdenka Pausova; Godfrey D Pearlson; Brenda W Penninx; Charles P Peterson; Andrea Pfennig; Mary Phillips; G Bruce Pike; Jean-Baptiste Poline; Steven G Potkin; Benno Pütz; Adaikalavan Ramasamy; Jerod Rasmussen; Marcella Rietschel; Mark Rijpkema; Shannon L Risacher; Joshua L Roffman; Roberto Roiz-Santiañez; Nina Romanczuk-Seiferth; Emma J Rose; Natalie A Royle; Dan Rujescu; Mina Ryten; Perminder S Sachdev; Alireza Salami; Theodore D Satterthwaite; Jonathan Savitz; Andrew J Saykin; Cathy Scanlon; Lianne Schmaal; Hugo G Schnack; Andrew J Schork; S Charles Schulz; Remmelt Schür; Larry Seidman; Li Shen; Jody M Shoemaker; Andrew Simmons; Sanjay M Sisodiya; Colin Smith; Jordan W Smoller; Jair C Soares; Scott R Sponheim; Emma Sprooten; John M Starr; Vidar M Steen; Stephen Strakowski; Lachlan Strike; Jessika Sussmann; Philipp G Sämann; Alexander Teumer; Arthur W Toga; Diana Tordesillas-Gutierrez; Daniah Trabzuni; Sarah Trost; Jessica Turner; Martijn Van den Heuvel; Nic J van der Wee; Kristel van Eijk; Theo G M van Erp; Neeltje E M van Haren; Dennis van 't Ent; Marie-Jose van Tol; Maria C Valdés Hernández; Dick J Veltman; Amelia Versace; Henry Völzke; Robert Walker; Henrik Walter; Lei Wang; Joanna M Wardlaw; Michael E Weale; Michael W Weiner; Wei Wen; Lars T Westlye; Heather C Whalley; Christopher D Whelan; Tonya White; Anderson M Winkler; Katharina Wittfeld; Girma Woldehawariat; Christiane Wolf; David Zilles; Marcel P Zwiers; Anbupalam Thalamuthu; Peter R Schofield; Nelson B Freimer; Natalia S Lawrence; Wayne Drevets
Journal: Brain Imaging Behav Date: 2014-06 Impact factor: 3.978

10. A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype.

Authors: Johanna Hass; Esther Walton; Holger Kirsten; Jingyu Liu; Lutz Priebe; Christiane Wolf; Nazanin Karbalai; Randy Gollub; Tonya White; Veit Roessner; Kathrin U Müller; Tomas Paus; Michael N Smolka; Gunter Schumann; Markus Scholz; Sven Cichon; Vince Calhoun; Stefan Ehrlich
Journal: PLoS One Date: 2013-06-21 Impact factor: 3.240