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Literature DB >> 22855263

Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents.

Peng Ren¹, Lucas-Alexandre Stern, Xile Hu.

Abstract

Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance.

Entities: Chemical

Year: 2012 PMID： 22855263 DOI： 10.1002/anie.201204275

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

9 in total

1. Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents.

Authors: Tie-Gen Chen; Haolin Zhang; Pavel K Mykhailiuk; Rohan R Merchant; Courtney A Smith; Tian Qin; Phil S Baran
Journal: Angew Chem Int Ed Engl Date: 2019-01-30 Impact factor: 15.336

2. Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates.

Authors: Meredith S Eno; Alexander Lu; James P Morken
Journal: J Am Chem Soc Date: 2016-06-16 Impact factor: 15.419

3. A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets.

Authors: Konstantin O Zhurov; Laure Menin; Thomas Di Franco; Yury O Tsybin
Journal: J Am Soc Mass Spectrom Date: 2015-04-21 Impact factor: 3.109

4. Fragment Coupling and the Construction of Quaternary Carbons Using Tertiary Radicals Generated From tert-Alkyl N-Phthalimidoyl Oxalates By Visible-Light Photocatalysis.

Authors: Gregory L Lackner; Kyle W Quasdorf; Gerald Pratsch; Larry E Overman
Journal: J Org Chem Date: 2015-06-01 Impact factor: 4.354

Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents.

1. Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents.

2. Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates.

3. A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets.

4. Fragment Coupling and the Construction of Quaternary Carbons Using Tertiary Radicals Generated From tert-Alkyl N-Phthalimidoyl Oxalates By Visible-Light Photocatalysis.

5. Ni-Catalyzed Arylboration of Unactivated Alkenes: Scope and Mechanistic Studies.

6. Iron-catalyzed cross-coupling of unactivated secondary alkyl thio ethers and sulfones with aryl Grignard reagents.

7. Catalyst-Controlled 1,2- and 1,1-Arylboration of α-Alkyl Alkenyl Arenes.

8. Copper-Catalyzed Cyclopropanol Ring Opening Csp(3)-Csp(3) Cross-Couplings with (Fluoro)Alkyl Halides.

9. Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives.