Literature DB >> 22854663

Comparison of stimulating effect on subpopulations of lymphocytes in human peripheral blood by methionine enkephalin with IL-2 and IFN-γ.

Hui Hua1, Changlong Lu, Weiwei Li, Jingjuan Meng, Danan Wang, Nicolas P Plotnikoff, Enhua Wang, Fengping Shan.   

Abstract

The aim of this study was to investigate the effects of mechanisms of methionine enkephalin (MENK) on lymphocytes in human peripheral blood. We detected CD4+T cells, CD8+T cells, CD4+CD25+ regulatory T cells (Treg), dendritic cells (DCs), natural killer cells (NK), NKT cells and γδT cells before and after treatment with 10 (-12) M MENK, in cell culture by FCM and RT-PCR. Our findings show that MENK stimulating expansion of lymphocyte subpopulationns by inhibiting CD4+CD25+ regulatory T cells (Treg), which is unique discovery of our study. We may use MENK as a drug to treat cancer patients, whose immune systems are damaged by chemotherapy or radiotherapy.

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Year:  2012        PMID： 22854663      PMCID： PMC3551880          DOI： 10.4161/hv.20759

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  40 in total

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Journal:  J Immunol       Date:  1997-03-15       Impact factor: 5.422

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Journal:  Am Fam Physician       Date:  1989-09       Impact factor: 3.292

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Journal:  Pol J Pharmacol       Date:  1995 Jul-Aug

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Authors:  H N Bhargava
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Review 7.  Methionine enkephalin: a new cytokine--human studies.

Authors:  N P Plotnikoff; R E Faith; A J Murgo; R B Herberman; R A Good
Journal:  Clin Immunol Immunopathol       Date:  1997-02

8.  Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrierer.

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Journal:  Int J Mol Med       Date:  2004-08       Impact factor: 4.101

9.  Effect of methionine enkephalin on natural killer cell and cytotoxic T lymphocyte activity in mice infected with influenza A virus.

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Journal:  Immunopharmacol Immunotoxicol       Date:  1995-05       Impact factor: 2.730

10.  In vitro studies of natural killer cell activity in post traumatic stress disorder patients. Response to methionine-enkephalin challenge.

Authors:  A D Mosnaim; M E Wolf; P Maturana; G Mosnaim; J Puente; O Kucuk; A Gilman-Sachs
Journal:  Immunopharmacology       Date:  1993 Mar-Apr
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  6 in total

1.  Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs).

Authors:  Qiushi Wang; Xinghua Gao; Zhe Yuan; Zhe Wang; Yiming Meng; Yan Cao; Nicolas P Plotnikoff; Noreen Griffin; Fengping Shan
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

2.  Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice.

Authors:  Xuan Li; Yiming Meng; Nicolas P Plotnikoff; Gene Youkilis; Noreen Griffin; Enhua Wang; Changlong Lu; Fengping Shan
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

3.  Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs).

Authors:  Yiming Meng; Qiushi Wang; Zhenjie Zhang; Enhua Wang; Nicollas P Plotnikoff; Fengping Shan
Journal:  Hum Vaccin Immunother       Date:  2013-03-07       Impact factor: 3.452

4.  Plasma Proenkephalin and Poor Long-Term Outcome in Renal Transplant Recipients.

Authors:  Lyanne M Kieneker; Oliver Hartmann; Joachim Struck; Andreas Bergmann; Ron T Gansevoort; Michel M Joosten; Else van den Berg; Rudolf A de Boer; Stephan J L Bakker
Journal:  Transplant Direct       Date:  2017-07-07

5.  Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery.

Authors:  Jana C Mossanen; Jessica Pracht; Tobias U Jansen; Lukas Buendgens; Christian Stoppe; Andreas Goetzenich; Joachim Struck; Rüdiger Autschbach; Gernot Marx; Frank Tacke
Journal:  Int J Mol Sci       Date:  2017-07-31       Impact factor: 5.923

6.  Killing effect of methionine enkephalin on melanoma in vivo and in vitro.

Authors:  Dong-Mei Wang; Xue Jiao; Nicolas P Plotnikoff; Noreen Griffin; Rui-Qun Qi; Xing-Hua Gao; Feng-Ping Shan
Journal:  Oncol Rep       Date:  2017-08-24       Impact factor: 3.906
  6 in total

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