BACKGROUND/AIMS: To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS: Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests. RESULTS: The DLB patients had a higher NPI totalscore (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003). CONCLUSIONS: In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.
BACKGROUND/AIMS: To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB). METHODS:Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests. RESULTS: The DLB patients had a higher NPI totalscore (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003). CONCLUSIONS: In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.
Authors: Maria I Lapid; Karen M Kuntz; Sara S Mason; Jeremiah A Aakre; Emily S Lundt; Walter Kremers; Laura A Allen; Daniel A Drubach; Bradley F Boeve Journal: Dement Geriatr Cogn Disord Date: 2017-04-28 Impact factor: 2.959
Authors: Guerry M Peavy; David P Salmon; Steven D Edland; Steven Tam; Lawrence A Hansen; Eliezer Masliah; Douglas Galasko; Joanne M Hamilton Journal: Am J Geriatr Psychiatry Date: 2013-03-13 Impact factor: 4.105
Authors: Françoise J Siepel; Arvid Rongve; Tirza C Buter; Mona K Beyer; Clive G Ballard; Jan Booij; Dag Aarsland Journal: BMJ Open Date: 2013-04-08 Impact factor: 2.692
Authors: A Rongve; H Soennesyn; Ragnhild Skogseth; Ragnhild Oesterhus; T Hortobágyi; Clive Ballard; B H Auestad; D Aarsland Journal: BMJ Open Date: 2016-02-29 Impact factor: 2.692