| Literature DB >> 22854380 |
Noorzaitun Ariffin1, Habsah Hasan, Noraida Ramli, Nor Rosidah Ibrahim, Fahisham Taib, Azriani Ab Rahman, Zeehaida Mohamed, Suhaimi Wahab, David Isaacs, Hans Van Rostenberghe.
Abstract
Intrahospital variations in antimicrobial profiles may be related to many factors. This study compared causative agents of nosocomial bloodstream infections between a neonatal intensive care unit (NICU) that adopted a ward-tailored antibiotic policy and adult intensive care units (ICUs). Data on organisms from blood cultures obtained from the respective wards between 2005 and 2009 were analyzed. Compared with the adult ICUs, the NICU had a higher frequency of Enterobacteriacae and lower frequencies of typical hospital-acquired pathogens (eg, Klebsiella pneumoniae, 17.4% vs 10.0% [P < .001]; Acinetobacter baumannii, 3.9% vs 11.6% [P < .001]). Antibiotic resistance of gram-negative organisms was also significantly lower in the NICU, including resistance to imipenem (5.7% vs 32.1%; P < .001), amikacin (8.8% vs 30.3%), and ceftriaxone (36.1% vs 74.6%; P < .001). This could possibly be due to the ward-tailored antibiotic policy adopted by the NICU but not by the other ICUs.Entities:
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Year: 2012 PMID： 22854380 DOI： 10.1016/j.ajic.2012.02.032
Source DB: PubMed Journal: Am J Infect Control ISSN： 0196-6553 Impact factor: 2.918