Literature DB >> 22854260

Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction.

Luke S Heuer1, Melissa Rose, Paul Ashwood, Judy Van de Water.   

Abstract

Autism spectrum disorders are a heterogeneous group of behaviorally defined disorders having complex etiologies. We previously reported a direct correlation between lower plasma levels of the immunoglobulins (Ig) IgG and IgM and increased severity of behavioral symptoms in children with autism. Our current objective was to determine if these reduced plasma levels of IgG and IgM are the result of defective B cell development, activation, or function. Results suggest no differences in the B cell parameters measured, indicating that decreased Ig in autism is not a result of B cell dysfunction and other immune cells might be involved.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22854260      PMCID： PMC3432686          DOI： 10.1016/j.jneuroim.2012.07.001

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  35 in total

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Journal:  Psychol Med       Date:  2002-11       Impact factor: 7.723

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Journal:  J Autism Dev Disord       Date:  1995-08

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Journal:  J Neuroimmunol       Date:  1998-05-01       Impact factor: 3.478

8.  Lymphocyte function in autism and Rett syndrome.

Authors:  A V Plioplys; A Greaves; K Kazemi; E Silverman
Journal:  Neuropsychobiology       Date:  1994       Impact factor: 2.328

9.  DR-positive T cells in autism: association with decreased plasma levels of the complement C4B protein.

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Journal:  Neuropsychobiology       Date:  1995       Impact factor: 2.328

10.  Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology.

Authors:  Paul Ashwood; Andrew Anthony; Alicia A Pellicer; Franco Torrente; John A Walker-Smith; Andrew J Wakefield
Journal:  J Clin Immunol       Date:  2003-11       Impact factor: 8.317
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  11 in total

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Review 2.  Immune Abnormalities in Autism Spectrum Disorder-Could They Hold Promise for Causative Treatment?

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Journal:  Neuropsychopharmacology       Date:  2016-08-18       Impact factor: 7.853

5.  Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study.

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Journal:  J Neuroinflammation       Date:  2014-06-20       Impact factor: 8.322

6.  Association between Asthma and Autism Spectrum Disorder: A Meta-Analysis.

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Review 7.  Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders.

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Review 8.  Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes.

Authors:  Richard E Frye; Daniel A Rossignol
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Review 9.  Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.

Authors:  Heather K Hughes; Emily Mills Ko; Destanie Rose; Paul Ashwood
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Review 10.  Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?

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