Literature DB >> 2285295

Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system.

P Silley1, J W Griffiths, D Monsey, A M Harris.   

Abstract

GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at low concentrations, essentially removing the permeability barrier for antibiotic uptake.

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Year:  1990        PMID： 2285295      PMCID： PMC171932          DOI： 10.1128/AAC.34.9.1806

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Segregation of New Lysogenic Types during Growth of a Doubly Lysogenic Strain Derived from Escherichia Coli K12.

Authors:  R K Appleyard
Journal:  Genetics       Date:  1954-07       Impact factor: 4.562

2.  E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system.

Authors:  N A Watanabe; T Nagasu; K Katsu; K Kitoh
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

Review 3.  Iron and infection.

Authors:  E D Weinberg
Journal:  Microbiol Rev       Date:  1978-03

Review 4.  Microbial iron compounds.

Authors:  J B Neilands
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

Review 5.  The significance of iron in infection.

Authors:  J J Bullen
Journal:  Rev Infect Dis       Date:  1981 Nov-Dec

6.  Properties of the penicillin-binding proteins of Escherichia coli K12,.

Authors:  B G Spratt
Journal:  Eur J Biochem       Date:  1977-01

7.  Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.

Authors:  M H Richmond; D C Clark; S Wotton
Journal:  Antimicrob Agents Chemother       Date:  1976-08       Impact factor: 5.191

8.  Excretion of enterochelin by exbA and exbB mutants of Escherichia coli.

Authors:  S K Guterman; L Dann
Journal:  J Bacteriol       Date:  1973-06       Impact factor: 3.490

9.  Iron transport in Escherichia coli: uptake and modification of ferrichrome.

Authors:  A Hartmann; V Braun
Journal:  J Bacteriol       Date:  1980-07       Impact factor: 3.490

10.  Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain.

Authors:  W Zimmermann
Journal:  Antimicrob Agents Chemother       Date:  1980-07       Impact factor: 5.191
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  25 in total

1.  In vitro activity of a catechol-substituted cephalosporin, GR69153.

Authors:  R Wise; J M Andrews; J P Ashby; D Thornber
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

2.  Evaluation of growth promotion and inhibition from mycobactins and nonmycobacterial siderophores (Desferrioxamine and FR160) in Mycobacterium aurum.

Authors:  S Bosne-David; L Bricard; F Ramiandrasoa; A DeRoussent; G Kunesch; A Andremont
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Disk diffusion susceptibility test interpretive criteria for GR69153, a new catechol-substituted cephalosporin.

Authors:  R N Jones; M E Erwin
Journal:  J Clin Microbiol       Date:  1991-12       Impact factor: 5.948

4.  In vitro comparison of GR69153, a novel catechol-substituted cephalosporin, with ceftazidime and ceftriaxone against 5,203 recent clinical isolates.

Authors:  J A Washington; R N Jones; S D Allen; E H Gerlach; F P Koontz; P R Murray; M A Pfaller; M E Erwin
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

5.  In vitro evaluation of GR69153, a novel catechol-substituted cephalosporin.

Authors:  M E Erwin; R N Jones; M S Barrett; B M Briggs; D M Johnson
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

6.  In vitro evaluation of Ro 09-1227, a novel catechol-substituted cephalosporin.

Authors:  R N Jones; M E Erwin
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

7.  Susceptibility of Pseudomonas aeruginosa urinary tract isolates and influence of urinary tract conditions on antibiotic tolerance.

Authors:  Maike Narten; Nathalie Rosin; Max Schobert; Petra Tielen
Journal:  Curr Microbiol       Date:  2011-10-08       Impact factor: 2.188

8.  In vitro and in vivo activities of LB10522, a new catecholic cephalosporin.

Authors:  M Y Kim; J I Oh; K S Paek; Y Z Kim; I C Kim; J H Kwak
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

9.  Influence of zinc on Pseudomonas aeruginosa susceptibilities to imipenem.

Authors:  G L Cooper; A Louie; A L Baltch; R C Chu; R P Smith; W J Ritz; P Michelsen
Journal:  J Clin Microbiol       Date:  1993-09       Impact factor: 5.948

10.  Sideromycins: tools and antibiotics.

Authors:  Volkmar Braun; Avijit Pramanik; Thomas Gwinner; Martin Köberle; Erwin Bohn
Journal:  Biometals       Date:  2009-01-07       Impact factor: 2.949
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