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Literature DB >> 22851784

Antiemetic efficacy of promethazine on xylazine-induced emesis in cats.

Saeed Kolahian¹, Seyed Hosein Jarolmasjed.

Abstract

The prophylactic antiemetic effect of 3 dosages of promethazine injected into cats 1 h before administration of xylazine was compared with that of a saline solution. Prior treatment with 2 and 4 mg/kg of promethazine significantly reduced the frequency of emetic episodes. Promethazine may be used as a prophylactic antiemetic in cats treated with xylazine.

Entities: Chemical Disease Species

Mesh：

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Year: 2012 PMID： 22851784 PMCID： PMC3258836

Source DB: PubMed Journal: Can Vet J ISSN： 0008-5286 Impact factor: 1.008

14 in total

Review 1. Neuropharmacology of emesis induced by anti-cancer therapy.

Authors: P L Andrews; W G Rapeport; G J Sanger
Journal: Trends Pharmacol Sci Date: 1988-09 Impact factor: 14.819

2. Theory of antimotion sickness drug mechanisms.

Authors: C D Wood; A Graybiel
Journal: Aerosp Med Date: 1972-03

3. Effects of metoclopramide on emesis in cats sedated with xylazine hydrochloride.

Authors: Saeed Kolahian; Seyedhosein Jarolmasjed
Journal: J Feline Med Surg Date: 2010-12 Impact factor: 2.015

Review 4. Drugs for preventing postoperative nausea and vomiting.

Authors: J B Carlisle; C A Stevenson
Journal: Cochrane Database Syst Rev Date: 2006-07-19

Review 5. Neural mechanisms of emesis.

Authors: D O Carpenter
Journal: Can J Physiol Pharmacol Date: 1990-02 Impact factor: 2.273

Review 6. Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP).

Authors: Laura A Magee; Paolo Mazzotta; Gideon Koren
Journal: Am J Obstet Gynecol Date: 2002-05 Impact factor: 8.661

2. Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats.

Authors: Drielle D Guimaraes; Paul L R Andrews; John A Rudd; Valdir A Braga; Eugene Nalivaiko
Journal: Temperature (Austin) Date: 2015-10-27

2 in total

Antiemetic efficacy of promethazine on xylazine-induced emesis in cats.

Review 1. Neuropharmacology of emesis induced by anti-cancer therapy.

2. Theory of antimotion sickness drug mechanisms.

3. Effects of metoclopramide on emesis in cats sedated with xylazine hydrochloride.

Review 4. Drugs for preventing postoperative nausea and vomiting.

Review 5. Neural mechanisms of emesis.

Review 6. Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP).

7. Dexamethasone has a central antiemetic mechanism in decerebrated cats.

8. Role of the chemoreceptor trigger zone in histamine-induced emesis.

9. The neurokinin-1 antagonist activity of maropitant, an antiemetic drug for dogs, in a gerbil model.

10. Antagonism of the emetic action of xylazine by alpha-adrenoceptor blocking agents.

1. Anesthesia-inducing drugs also induce conditioned taste aversions.

2. Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats.